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Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

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Harvard

Skaaby, T, Kilpeläinen, TO, Taylor, AE, Mahendran, Y, Wong, A, Ahluwalia, TS, Paternoster, L, Trompet, S, Stott, DJ, Flexeder, C, Zhou, A, Brusselle, G, Sajjad, A, Lahousse, L, Tiemeier, H, Have, CT, Thuesen, BH, Kårhus, LL, Møllehave, LT, Leth-Møller, KB, Shabanzadeh, DM, Gonzalez-Quintela, A, Power, C, Hyppönen, E, Kuh, D, Hardy, R, Meitinger, T, Jukema, JW, Völker, U, Nauck, M, Völzke, H, Friedrich, N, Bonten, TN, Noordam, R, Mook-Kanamori, DO, Tolstrup, JS, Taube, C, Peters, A, Grallert, H, Strauch, K, Schulz, H, Grarup, N, Hansen, T, Pedersen, O, Burgess, S, Munafò, MR & Linneberg, A 2019, 'Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis', Addiction, bind 114, nr. 2, s. 216-225. https://doi.org/10.1111/add.14438

APA

Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., ... Linneberg, A. (2019). Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction, 114(2), 216-225. https://doi.org/10.1111/add.14438

CBE

Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C, Zhou A, Brusselle G, Sajjad A, Lahousse L, Tiemeier H, Have CT, Thuesen BH, Kårhus LL, Møllehave LT, Leth-Møller KB, Shabanzadeh DM, Gonzalez-Quintela A, Power C, Hyppönen E, Kuh D, Hardy R, Meitinger T, Jukema JW, Völker U, Nauck M, Völzke H, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Tolstrup JS, Taube C, Peters A, Grallert H, Strauch K, Schulz H, Grarup N, Hansen T, Pedersen O, Burgess S, Munafò MR, Linneberg A. 2019. Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction. 114(2):216-225. https://doi.org/10.1111/add.14438

MLA

Vancouver

Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS o.a. Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction. 2019 feb 1;114(2):216-225. https://doi.org/10.1111/add.14438

Author

Skaaby, Tea ; Kilpeläinen, Tuomas O ; Taylor, Amy E ; Mahendran, Yuvaraj ; Wong, Andrew ; Ahluwalia, Tarunveer S ; Paternoster, Lavinia ; Trompet, Stella ; Stott, David J ; Flexeder, Claudia ; Zhou, Ang ; Brusselle, Guy ; Sajjad, Ayesha ; Lahousse, Lies ; Tiemeier, Henning ; Have, Christian Theil ; Thuesen, Betina H ; Kårhus, Line Lund ; Møllehave, Line Tang ; Leth-Møller, Katja Biering ; Shabanzadeh, Daniel Mønsted ; Gonzalez-Quintela, Arturo ; Power, Chris ; Hyppönen, Elina ; Kuh, Diana ; Hardy, Rebecca ; Meitinger, Thomas ; Jukema, J Wouter ; Völker, Uwe ; Nauck, Matthias ; Völzke, Henry ; Friedrich, Nele ; Bonten, Tobias N ; Noordam, Raymond ; Mook-Kanamori, Dennis O ; Tolstrup, Janne S ; Taube, Christian ; Peters, Annette ; Grallert, Harald ; Strauch, Konstantin ; Schulz, Holger ; Grarup, Niels ; Hansen, Torben ; Pedersen, Oluf ; Burgess, Stephen ; Munafò, Marcus R ; Linneberg, Allan. / Association of alcohol consumption with allergic disease and asthma : a multi-centre Mendelian randomization analysis. I: Addiction. 2019 ; Bind 114, Nr. 2. s. 216-225.

Bibtex

@article{10c7e33c55cc4b92b9f27cacfd9a023c,
title = "Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis",
abstract = "AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization, and serum total IgE.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466434 persons aged 15-82 years from 17 population-based studies conducted from 1997-2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped, alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking vs. non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization, or serum total IgE. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR=0.91 (95% confidence interval (CI): 0.81, 1.02; p=0.101) for hay fever, an OR=0.90 (95% CI: 0.79, 1.02; p=0.095) for asthma, an OR=0.97 (95% CI: 0.80, 1.17; p=0.763) for allergic sensitization, and a 4.7% change (95% CI: -5.5%, 14.9%; p=0.366) for total IgE.CONCLUSIONS: Ever-drinking vs. not drinking was in observational analyses positively associated with hay fever, and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.",
keywords = "Alcohol, allergic disease, allergic sensitization, asthma, hay fever, mendelian randomization",
author = "Tea Skaaby and Kilpel{\"a}inen, {Tuomas O} and Taylor, {Amy E} and Yuvaraj Mahendran and Andrew Wong and Ahluwalia, {Tarunveer S} and Lavinia Paternoster and Stella Trompet and Stott, {David J} and Claudia Flexeder and Ang Zhou and Guy Brusselle and Ayesha Sajjad and Lies Lahousse and Henning Tiemeier and Have, {Christian Theil} and Thuesen, {Betina H} and K{\aa}rhus, {Line Lund} and M{\o}llehave, {Line Tang} and Leth-M{\o}ller, {Katja Biering} and Shabanzadeh, {Daniel M{\o}nsted} and Arturo Gonzalez-Quintela and Chris Power and Elina Hypp{\"o}nen and Diana Kuh and Rebecca Hardy and Thomas Meitinger and Jukema, {J Wouter} and Uwe V{\"o}lker and Matthias Nauck and Henry V{\"o}lzke and Nele Friedrich and Bonten, {Tobias N} and Raymond Noordam and Mook-Kanamori, {Dennis O} and Tolstrup, {Janne S} and Christian Taube and Annette Peters and Harald Grallert and Konstantin Strauch and Holger Schulz and Niels Grarup and Torben Hansen and Oluf Pedersen and Stephen Burgess and Munaf{\`o}, {Marcus R} and Allan Linneberg",
note = "{\textcopyright} 2018 Society for the Study of Addiction.",
year = "2019",
month = feb,
day = "1",
doi = "10.1111/add.14438",
language = "English",
volume = "114",
pages = "216--225",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Association of alcohol consumption with allergic disease and asthma

T2 - a multi-centre Mendelian randomization analysis

AU - Skaaby, Tea

AU - Kilpeläinen, Tuomas O

AU - Taylor, Amy E

AU - Mahendran, Yuvaraj

AU - Wong, Andrew

AU - Ahluwalia, Tarunveer S

AU - Paternoster, Lavinia

AU - Trompet, Stella

AU - Stott, David J

AU - Flexeder, Claudia

AU - Zhou, Ang

AU - Brusselle, Guy

AU - Sajjad, Ayesha

AU - Lahousse, Lies

AU - Tiemeier, Henning

AU - Have, Christian Theil

AU - Thuesen, Betina H

AU - Kårhus, Line Lund

AU - Møllehave, Line Tang

AU - Leth-Møller, Katja Biering

AU - Shabanzadeh, Daniel Mønsted

AU - Gonzalez-Quintela, Arturo

AU - Power, Chris

AU - Hyppönen, Elina

AU - Kuh, Diana

AU - Hardy, Rebecca

AU - Meitinger, Thomas

AU - Jukema, J Wouter

AU - Völker, Uwe

AU - Nauck, Matthias

AU - Völzke, Henry

AU - Friedrich, Nele

AU - Bonten, Tobias N

AU - Noordam, Raymond

AU - Mook-Kanamori, Dennis O

AU - Tolstrup, Janne S

AU - Taube, Christian

AU - Peters, Annette

AU - Grallert, Harald

AU - Strauch, Konstantin

AU - Schulz, Holger

AU - Grarup, Niels

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Burgess, Stephen

AU - Munafò, Marcus R

AU - Linneberg, Allan

N1 - © 2018 Society for the Study of Addiction.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization, and serum total IgE.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466434 persons aged 15-82 years from 17 population-based studies conducted from 1997-2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped, alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking vs. non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization, or serum total IgE. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR=0.91 (95% confidence interval (CI): 0.81, 1.02; p=0.101) for hay fever, an OR=0.90 (95% CI: 0.79, 1.02; p=0.095) for asthma, an OR=0.97 (95% CI: 0.80, 1.17; p=0.763) for allergic sensitization, and a 4.7% change (95% CI: -5.5%, 14.9%; p=0.366) for total IgE.CONCLUSIONS: Ever-drinking vs. not drinking was in observational analyses positively associated with hay fever, and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

AB - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization, and serum total IgE.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466434 persons aged 15-82 years from 17 population-based studies conducted from 1997-2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped, alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking vs. non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization, or serum total IgE. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR=0.91 (95% confidence interval (CI): 0.81, 1.02; p=0.101) for hay fever, an OR=0.90 (95% CI: 0.79, 1.02; p=0.095) for asthma, an OR=0.97 (95% CI: 0.80, 1.17; p=0.763) for allergic sensitization, and a 4.7% change (95% CI: -5.5%, 14.9%; p=0.366) for total IgE.CONCLUSIONS: Ever-drinking vs. not drinking was in observational analyses positively associated with hay fever, and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

KW - Alcohol

KW - allergic disease

KW - allergic sensitization

KW - asthma

KW - hay fever

KW - mendelian randomization

UR - http://www.scopus.com/inward/record.url?scp=85055872567&partnerID=8YFLogxK

U2 - 10.1111/add.14438

DO - 10.1111/add.14438

M3 - Journal article

C2 - 30209858

VL - 114

SP - 216

EP - 225

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 2

ER -

ID: 55197924