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Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy

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Harvard

Zeiler, FA, Ercole, A, Placek, MM, Hutchinson, PJ, Stocchetti, N, Czosnyka, M, Smielewski, P, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators, Kondziella, D & Møller, K 2021, 'Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy', Journal of Neurotrauma, bind 38, nr. 2, s. 272-282. https://doi.org/10.1089/neu.2020.7249

APA

Zeiler, F. A., Ercole, A., Placek, M. M., Hutchinson, P. J., Stocchetti, N., Czosnyka, M., Smielewski, P., CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators, Kondziella, D., & Møller, K. (2021). Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy. Journal of Neurotrauma, 38(2), 272-282. https://doi.org/10.1089/neu.2020.7249

CBE

Zeiler FA, Ercole A, Placek MM, Hutchinson PJ, Stocchetti N, Czosnyka M, Smielewski P, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators, Kondziella D, Møller K. 2021. Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy. Journal of Neurotrauma. 38(2):272-282. https://doi.org/10.1089/neu.2020.7249

MLA

Vancouver

Author

Zeiler, Frederick A ; Ercole, Ari ; Placek, Michal M ; Hutchinson, Peter J ; Stocchetti, Nino ; Czosnyka, Marek ; Smielewski, Peter ; CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators ; Kondziella, Daniel ; Møller, Kirsten. / Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury : A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy. I: Journal of Neurotrauma. 2021 ; Bind 38, Nr. 2. s. 272-282.

Bibtex

@article{98e2c5aa7a2248d89425013b72892b3c,
title = "Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy",
abstract = "In traumatic brain injury (TBI), preliminary retrospective work on signal entropy suggests an association with global outcome. The goal of this study was to provide multi-center validation of the association between multi-scale entropy (MSE) of cardiovascular and cerebral physiological signals, with six-month outcome. Using the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) high-resolution intensive care unit (ICU) cohort, we selected patients with a minimum of 72 h of physiological recordings and a documented six-month Glasgow Outcome Scale Extended (GOSE) score. The 10-sec summary data for heart rate (HR), mean arterial pressure (MAP), intracranial pressure (ICP), and pulse amplitude of ICP (AMP) were derived across the first 72 h of data. The MSE complexity index (MSE-Ci) was determined for HR, MAP, ICP, and AMP, with the association between MSE and dichotomized six-month outcomes assessed using Mann-Whitney U testing and logistic regression analysis. A total of 160 patients had a minimum of 72 h of recording and a documented outcome. Decreased HR MSE-Ci (7.3 [interquartile range (IQR) 5.4 to 10.2] vs. 5.1 [IQR 3.1 to 7.0]; p = 0.002), lower ICP MSE-Ci (11.2 [IQR 7.5 to 14.2] vs. 7.3 [IQR 6.1 to 11.0]; p = 0.009), and lower AMP MSE-Ci (10.9 [IQR 8.0 to 13.7] vs. 8.7 [IQR 6.6 to 11.0]; p = 0.022), were associated with death. Similarly, lower HR MSE-Ci (8.0 [IQR 6.2 to 10.9] vs. 6.2 [IQR 3.9 to 8.7]; p = 0.003) and lower ICP MSE-Ci (11.4 [IQR 8.6 to 14.4)] vs. 9.2 [IQR 6.0 to 13.5]), were associated with unfavorable outcome. Logistic regression analysis confirmed that lower HR MSE-Ci and ICP MSE-Ci were associated with death and unfavorable outcome at six months. These findings suggest that a reduction in cardiovascular and cerebrovascular system entropy is associated with worse outcomes. Further work in the field of signal complexity in TBI multi-modal monitoring is required.",
keywords = "autoregulation, cerebral physiology, complexity, multi-scale entropy, outcome",
author = "Zeiler, {Frederick A} and Ari Ercole and Placek, {Michal M} and Hutchinson, {Peter J} and Nino Stocchetti and Marek Czosnyka and Peter Smielewski and {CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators} and Daniel Kondziella and Kirsten M{\o}ller",
year = "2021",
month = jan,
day = "15",
doi = "10.1089/neu.2020.7249",
language = "English",
volume = "38",
pages = "272--282",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury

T2 - A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy

AU - Zeiler, Frederick A

AU - Ercole, Ari

AU - Placek, Michal M

AU - Hutchinson, Peter J

AU - Stocchetti, Nino

AU - Czosnyka, Marek

AU - Smielewski, Peter

AU - CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators

A2 - Kondziella, Daniel

A2 - Møller, Kirsten

PY - 2021/1/15

Y1 - 2021/1/15

N2 - In traumatic brain injury (TBI), preliminary retrospective work on signal entropy suggests an association with global outcome. The goal of this study was to provide multi-center validation of the association between multi-scale entropy (MSE) of cardiovascular and cerebral physiological signals, with six-month outcome. Using the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) high-resolution intensive care unit (ICU) cohort, we selected patients with a minimum of 72 h of physiological recordings and a documented six-month Glasgow Outcome Scale Extended (GOSE) score. The 10-sec summary data for heart rate (HR), mean arterial pressure (MAP), intracranial pressure (ICP), and pulse amplitude of ICP (AMP) were derived across the first 72 h of data. The MSE complexity index (MSE-Ci) was determined for HR, MAP, ICP, and AMP, with the association between MSE and dichotomized six-month outcomes assessed using Mann-Whitney U testing and logistic regression analysis. A total of 160 patients had a minimum of 72 h of recording and a documented outcome. Decreased HR MSE-Ci (7.3 [interquartile range (IQR) 5.4 to 10.2] vs. 5.1 [IQR 3.1 to 7.0]; p = 0.002), lower ICP MSE-Ci (11.2 [IQR 7.5 to 14.2] vs. 7.3 [IQR 6.1 to 11.0]; p = 0.009), and lower AMP MSE-Ci (10.9 [IQR 8.0 to 13.7] vs. 8.7 [IQR 6.6 to 11.0]; p = 0.022), were associated with death. Similarly, lower HR MSE-Ci (8.0 [IQR 6.2 to 10.9] vs. 6.2 [IQR 3.9 to 8.7]; p = 0.003) and lower ICP MSE-Ci (11.4 [IQR 8.6 to 14.4)] vs. 9.2 [IQR 6.0 to 13.5]), were associated with unfavorable outcome. Logistic regression analysis confirmed that lower HR MSE-Ci and ICP MSE-Ci were associated with death and unfavorable outcome at six months. These findings suggest that a reduction in cardiovascular and cerebrovascular system entropy is associated with worse outcomes. Further work in the field of signal complexity in TBI multi-modal monitoring is required.

AB - In traumatic brain injury (TBI), preliminary retrospective work on signal entropy suggests an association with global outcome. The goal of this study was to provide multi-center validation of the association between multi-scale entropy (MSE) of cardiovascular and cerebral physiological signals, with six-month outcome. Using the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) high-resolution intensive care unit (ICU) cohort, we selected patients with a minimum of 72 h of physiological recordings and a documented six-month Glasgow Outcome Scale Extended (GOSE) score. The 10-sec summary data for heart rate (HR), mean arterial pressure (MAP), intracranial pressure (ICP), and pulse amplitude of ICP (AMP) were derived across the first 72 h of data. The MSE complexity index (MSE-Ci) was determined for HR, MAP, ICP, and AMP, with the association between MSE and dichotomized six-month outcomes assessed using Mann-Whitney U testing and logistic regression analysis. A total of 160 patients had a minimum of 72 h of recording and a documented outcome. Decreased HR MSE-Ci (7.3 [interquartile range (IQR) 5.4 to 10.2] vs. 5.1 [IQR 3.1 to 7.0]; p = 0.002), lower ICP MSE-Ci (11.2 [IQR 7.5 to 14.2] vs. 7.3 [IQR 6.1 to 11.0]; p = 0.009), and lower AMP MSE-Ci (10.9 [IQR 8.0 to 13.7] vs. 8.7 [IQR 6.6 to 11.0]; p = 0.022), were associated with death. Similarly, lower HR MSE-Ci (8.0 [IQR 6.2 to 10.9] vs. 6.2 [IQR 3.9 to 8.7]; p = 0.003) and lower ICP MSE-Ci (11.4 [IQR 8.6 to 14.4)] vs. 9.2 [IQR 6.0 to 13.5]), were associated with unfavorable outcome. Logistic regression analysis confirmed that lower HR MSE-Ci and ICP MSE-Ci were associated with death and unfavorable outcome at six months. These findings suggest that a reduction in cardiovascular and cerebrovascular system entropy is associated with worse outcomes. Further work in the field of signal complexity in TBI multi-modal monitoring is required.

KW - autoregulation

KW - cerebral physiology

KW - complexity

KW - multi-scale entropy

KW - outcome

UR - http://www.scopus.com/inward/record.url?scp=85098790723&partnerID=8YFLogxK

U2 - 10.1089/neu.2020.7249

DO - 10.1089/neu.2020.7249

M3 - Journal article

C2 - 32814492

VL - 38

SP - 272

EP - 282

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 2

ER -

ID: 61291626