Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital

Assessment Of The Correlation Between Dynamic Contrast Enhanced Computed Tomography And Histological And Vascular Biomarkers In Patients Resected For Colorectal Liver Metastases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Carotid plaque imaging with FDG-PET and ultrasound

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Evaluation of competence in ultrasound-guided procedures-a generic assessment tool developed through the Delphi method

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Simulation-based training in ultrasound - where are we now?

    Publikation: Bidrag til tidsskriftLederpeer review

  3. Four-Dimensional Flow MRI of Abdominal Veins: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewpeer review

Vis graf over relationer
Background: Dynamic contrast-enhanced computed tomography (DCE-CT) is a promising noninvasive method that provides the functional evaluation of the vascularity in normal and malignant tissue. The objectives of this consecutive study were to investigate the possible correlation between the perfusion characteristics of colorectal cancer liver metastases as examined by (DCE-CT) and the microvessel density of resected metastases. An additional aim was to investigate the correlation between the urokinase plasminogen activation receptor (uPAR) and perfusion values. Methods and findings: Eleven patients fulfilled the criteria for comparative analyses. The microvessel density values, uPAR level and the DCE-CT values were analysed. A perfusion index (PI) based on the measurement of arterial and portal flow (AF, PF) was defined as follows: PI=AF/(AF+PF)%. The DCE-CT measurements were compared between metastatic and normal liver tissues. A Spearman correlation test was used for statistical analysis. The perfusion index and microvessel density values were significantly correlated (r=0.75; p=0.01). Furthermore, a higher volume of metastases significantly correlated with higher plasma levels of the uPAR forms (0.72 ≤ r ≥ 0.89; p<0.05). Conclusions: DCE-CT may have the potential to measure the vascularity of colorectal liver metastases; however, the correlation between microvessel density and the perfusion values appears vague.
TidsskriftImaging in Medicine
Udgave nummer6
Sider (fra-til)147-154
StatusUdgivet - 2018

ID: 56563176