TY - JOUR

T1 - Assessment of Predictors of Left Atrial Volume Response to a Transcatheter InterAtrial Shunt Device (from the REDUCE LAP-HF Trial)

AU - Hanff, Thomas C

AU - Kaye, David M

AU - Hayward, Christopher S

AU - Post, Martijn C

AU - Malek, Filip

AU - Hasenfuβ, Gerd

AU - Gustafsson, Finn

AU - Burkhoff, Daniel

AU - Shah, Sanjiv J

AU - Litwin, Sheldon E

AU - Kahwash, Rami

AU - Hummel, Scott L

AU - Borlaug, Barry A

AU - Solomon, Scott D

AU - Lam, Carolyn S P

AU - Komtebedde, Jan

AU - Silvestry, Frank E

AU - REDUCE LAP-HF study investigators, and research staff

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/12/15

Y1 - 2019/12/15

N2 - In patients with heart failure and preserved or mildly reduced ejection fractions (EF ≥40%), implantation of an interatrial shunt device (IASD) resulted in heterogenous changes of the left atrial (LA) volume. Baseline characteristics that correlate with a favorable decrease in LA volume are unknown. We hypothesized that a larger ratio of left to right atrial volume at baseline would correlate strongly with LA volume decongestion following IASD implantation. Reduce Elevated LA Pressure in Patients With Heart Failure was a multicenter study of the safety and feasibility of IASD implantation. Sixty-four patients with EF ≥40% underwent device implantation along with baseline conventional echocardiograms, speckle tracking echocardiography, and resting and exercise hemodynamics. Higher LA compliance (-4.2%, p = 0.048) and right atrial reservoir strain (-0.8%, p = 0.005) were independently associated with a percent decrease in the systolic LA volume index from baseline to 6-months. In conclusion, greater LA volume reduction following IASD implantation is associated with higher baseline compliance of the left atrium and higher reservoir strain of the right atrium.

AB - In patients with heart failure and preserved or mildly reduced ejection fractions (EF ≥40%), implantation of an interatrial shunt device (IASD) resulted in heterogenous changes of the left atrial (LA) volume. Baseline characteristics that correlate with a favorable decrease in LA volume are unknown. We hypothesized that a larger ratio of left to right atrial volume at baseline would correlate strongly with LA volume decongestion following IASD implantation. Reduce Elevated LA Pressure in Patients With Heart Failure was a multicenter study of the safety and feasibility of IASD implantation. Sixty-four patients with EF ≥40% underwent device implantation along with baseline conventional echocardiograms, speckle tracking echocardiography, and resting and exercise hemodynamics. Higher LA compliance (-4.2%, p = 0.048) and right atrial reservoir strain (-0.8%, p = 0.005) were independently associated with a percent decrease in the systolic LA volume index from baseline to 6-months. In conclusion, greater LA volume reduction following IASD implantation is associated with higher baseline compliance of the left atrium and higher reservoir strain of the right atrium.

U2 - 10.1016/j.amjcard.2019.09.019

DO - 10.1016/j.amjcard.2019.09.019

M3 - Journal article

VL - 124

SP - 1912

EP - 1917

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 12

ER -