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Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study

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  1. Data Resource Profile: The Copenhagen Hospital Biobank (CHB)

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  2. Male origin microchimerism and ovarian cancer

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  3. Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

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  4. Cohort Profile: The Copenhagen Child Cohort Study (CCC2000)

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  5. Data Resource Profile: Committee of Nordic Assisted Reproductive Technology and Safety (CoNARTaS) cohort

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  1. Noncoding RNA (ncRNA) Profile Association with Patient Outcome in Epithelial Ovarian Cancer Cases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Postoperative mobilisation as an indicator for the quality of surgical nursing care

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ovariecancerbehandling i Danmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Jue-Sheng Ong
  • Liang-Dar Hwang
  • Gabriel Cuellar-Partida
  • Nicholas G Martin
  • Georgia Chenevix-Trench
  • Michael C J Quinn
  • Marilyn C Cornelis
  • Puya Gharahkhani
  • Penelope M Webb
  • Stuart MacGregor
  • Ovarian Cancer Association Consortium
  • Claus K. Høgdall (Medlem af forfattergruppering)
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Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.

Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.

Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.

Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

OriginalsprogEngelsk
TidsskriftInternational Journal of Epidemiology
Vol/bind47
Udgave nummer2
Sider (fra-til)450-459
ISSN0300-5771
DOI
StatusUdgivet - 2018

ID: 52205555