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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Antithyroid drug-induced fetal goitrous hypothyroidism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.
OriginalsprogEngelsk
TidsskriftNature reviews. Endocrinology
Vol/bind7
Udgave nummer7
Sider (fra-til)396-406
Antal sider11
DOI
StatusUdgivet - 1 jan. 2011

ID: 32364170