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Antipsychotics and associated risk of out-of-hospital cardiac arrest

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Harvard

Weeke, P, Jensen, A, Folke, F, Gislason, GH, Olesen, JB, Fosbøl, EL, Wissenberg, M, Lippert, FK, Christensen, EF, Nielsen, SL, Holm, E, Kanters, JK, Poulsen, HE, Køber, L & Torp-Pedersen, C 2014, 'Antipsychotics and associated risk of out-of-hospital cardiac arrest' Clinical Pharmacology and Therapeutics, bind 96, nr. 4, s. 490-497. https://doi.org/10.1038/clpt.2014.139

APA

Weeke, P., Jensen, A., Folke, F., Gislason, G. H., Olesen, J. B., Fosbøl, E. L., ... Torp-Pedersen, C. (2014). Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clinical Pharmacology and Therapeutics, 96(4), 490-497. https://doi.org/10.1038/clpt.2014.139

CBE

Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Fosbøl EL, Wissenberg M, Lippert FK, Christensen EF, Nielsen SL, Holm E, Kanters JK, Poulsen HE, Køber L, Torp-Pedersen C. 2014. Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clinical Pharmacology and Therapeutics. 96(4):490-497. https://doi.org/10.1038/clpt.2014.139

MLA

Vancouver

Author

Weeke, Peter ; Jensen, Aksel ; Folke, Fredrik ; Gislason, Gunnar Hilmar ; Olesen, Jonas Bjerring ; Fosbøl, Emil L ; Wissenberg, Mads ; Lippert, Freddy K ; Christensen, Erika Frischknecht ; Nielsen, Søren Loumann ; Holm, Ellen ; Kanters, Jørgen K ; Poulsen, Henrik Enghusen ; Køber, Lars ; Torp-Pedersen, Christian. / Antipsychotics and associated risk of out-of-hospital cardiac arrest. I: Clinical Pharmacology and Therapeutics. 2014 ; Bind 96, Nr. 4. s. 490-497.

Bibtex

@article{d636e9255f7a4fdeb2d92b40159e2a12,
title = "Antipsychotics and associated risk of out-of-hospital cardiac arrest",
abstract = "Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6{\%}) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95{\%} confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.",
author = "Peter Weeke and Aksel Jensen and Fredrik Folke and Gislason, {Gunnar Hilmar} and Olesen, {Jonas Bjerring} and Fosb{\o}l, {Emil L} and Mads Wissenberg and Lippert, {Freddy K} and Christensen, {Erika Frischknecht} and Nielsen, {S{\o}ren Loumann} and Ellen Holm and Kanters, {J{\o}rgen K} and Poulsen, {Henrik Enghusen} and Lars K{\o}ber and Christian Torp-Pedersen",
year = "2014",
doi = "10.1038/clpt.2014.139",
language = "English",
volume = "96",
pages = "490--497",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Antipsychotics and associated risk of out-of-hospital cardiac arrest

AU - Weeke, Peter

AU - Jensen, Aksel

AU - Folke, Fredrik

AU - Gislason, Gunnar Hilmar

AU - Olesen, Jonas Bjerring

AU - Fosbøl, Emil L

AU - Wissenberg, Mads

AU - Lippert, Freddy K

AU - Christensen, Erika Frischknecht

AU - Nielsen, Søren Loumann

AU - Holm, Ellen

AU - Kanters, Jørgen K

AU - Poulsen, Henrik Enghusen

AU - Køber, Lars

AU - Torp-Pedersen, Christian

PY - 2014

Y1 - 2014

N2 - Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

AB - Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

U2 - 10.1038/clpt.2014.139

DO - 10.1038/clpt.2014.139

M3 - Journal article

VL - 96

SP - 490

EP - 497

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 4

ER -

ID: 44372023