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Antiherpetic medication and incident dementia: Observational cohort studies in four countries

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Christian Schnier
  • Janet Janbek
  • Linda Williams
  • Tim Wilkinson
  • Thomas M Laursen
  • Gunhild Waldemar
  • Hartmut Richter
  • Karel Kostev
  • Richard Lathe
  • Jürgen G Haas
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BACKGROUND AND PURPOSE: Several epidemiological studies from Taiwan, all using the same data resource, found significant associations between herpes virus infection, antiherpetic medication, and subsequent dementia. We conducted a multicenter observational cohort study using health registry data from Wales, Germany, Scotland, and Denmark to investigate potential associations between antiherpetic medication and incident dementia, and also to comprehensively investigate such associations broken down according to medication type and dose, type of herpes virus, and dementia subtype.

METHODS: A total of 2.5 million individuals aged 65 years or more were followed up using linked electronic health records in four national observational cohort studies. Exposure and outcome were classified using coded data from primary and secondary care. Data were analyzed using survival analysis with time-dependent covariates.

RESULTS: Results were heterogeneous, with a tendency toward decreased dementia risk in individuals exposed to antiherpetic medication. Associations were not affected by treatment number, herpes subtype, dementia subtype, or specific medication. In one cohort, individuals diagnosed with herpes but not exposed to antiherpetic medication were at higher dementia risk.

CONCLUSIONS: Short-term antiherpetic medication is not markedly associated with incident dementia. Because neither dementia subtype nor herpes subtype modified the association, the small but significant decrease in dementia incidence with antiherpetic administration may reflect confounding and misclassification.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
Vol/bind28
Udgave nummer6
Sider (fra-til)1840-1848
Antal sider9
ISSN1351-5101
DOI
StatusUdgivet - jun. 2021

ID: 65067596