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Antidepressant Use in Siblings of Children With Cancer: A Danish Population-Based Cohort Study

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Author

Lund, Lasse Wegener ; Winther, Jeanette Falck ; Cederkvist, Luise ; Rechnitzer, Catherine ; Dalton, Susanne Oksbjerg ; Appel, Charlotte Weiling ; Schmiegelow, Kjeld ; Johansen, Christoffer. / Antidepressant Use in Siblings of Children With Cancer : A Danish Population-Based Cohort Study. I: JNCI cancer spectrum. 2020 ; Bind 4, Nr. 5. s. pkaa046.

Bibtex

@article{37540d53a8814391ad9bc0e8400f11b2,
title = "Antidepressant Use in Siblings of Children With Cancer: A Danish Population-Based Cohort Study",
abstract = "Siblings of children with cancer experience severe stress early in life. Most studies of mental health problems in these siblings are limited by being small, cross-sectional, or self-reporting. In a population-based cohort study, we investigated the risk for antidepressant use by linking several nationwide, population-based registries comparing 6644 siblings of children diagnosed with cancer from 1991-2009 with 128 436 population-based sibling comparisons using the Cox proportional hazards model. Irrespective of cancer type, no increased risk of antidepressant use in siblings of children with cancer was found (hazard ratio = 1.00, 95% confidence interval = 0.91 to 1.11). However, data suggested that siblings being young at cancer diagnosis had an increased risk (2-sided Ptrend = .01). Interaction analyses showed no modifying effect of parental socioeconomic position or antidepressant use. Findings from this study with a very low risk of bias are reassuring and important for families facing childhood cancer and for clinicians counseling these families.",
author = "Lund, {Lasse Wegener} and Winther, {Jeanette Falck} and Luise Cederkvist and Catherine Rechnitzer and Dalton, {Susanne Oksbjerg} and Appel, {Charlotte Weiling} and Kjeld Schmiegelow and Christoffer Johansen",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press.",
year = "2020",
month = oct,
doi = "10.1093/jncics/pkaa046",
language = "English",
volume = "4",
pages = "pkaa046",
journal = "JNCI Cancer Spectrum",
issn = "2515-5091",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Antidepressant Use in Siblings of Children With Cancer

T2 - A Danish Population-Based Cohort Study

AU - Lund, Lasse Wegener

AU - Winther, Jeanette Falck

AU - Cederkvist, Luise

AU - Rechnitzer, Catherine

AU - Dalton, Susanne Oksbjerg

AU - Appel, Charlotte Weiling

AU - Schmiegelow, Kjeld

AU - Johansen, Christoffer

N1 - © The Author(s) 2020. Published by Oxford University Press.

PY - 2020/10

Y1 - 2020/10

N2 - Siblings of children with cancer experience severe stress early in life. Most studies of mental health problems in these siblings are limited by being small, cross-sectional, or self-reporting. In a population-based cohort study, we investigated the risk for antidepressant use by linking several nationwide, population-based registries comparing 6644 siblings of children diagnosed with cancer from 1991-2009 with 128 436 population-based sibling comparisons using the Cox proportional hazards model. Irrespective of cancer type, no increased risk of antidepressant use in siblings of children with cancer was found (hazard ratio = 1.00, 95% confidence interval = 0.91 to 1.11). However, data suggested that siblings being young at cancer diagnosis had an increased risk (2-sided Ptrend = .01). Interaction analyses showed no modifying effect of parental socioeconomic position or antidepressant use. Findings from this study with a very low risk of bias are reassuring and important for families facing childhood cancer and for clinicians counseling these families.

AB - Siblings of children with cancer experience severe stress early in life. Most studies of mental health problems in these siblings are limited by being small, cross-sectional, or self-reporting. In a population-based cohort study, we investigated the risk for antidepressant use by linking several nationwide, population-based registries comparing 6644 siblings of children diagnosed with cancer from 1991-2009 with 128 436 population-based sibling comparisons using the Cox proportional hazards model. Irrespective of cancer type, no increased risk of antidepressant use in siblings of children with cancer was found (hazard ratio = 1.00, 95% confidence interval = 0.91 to 1.11). However, data suggested that siblings being young at cancer diagnosis had an increased risk (2-sided Ptrend = .01). Interaction analyses showed no modifying effect of parental socioeconomic position or antidepressant use. Findings from this study with a very low risk of bias are reassuring and important for families facing childhood cancer and for clinicians counseling these families.

U2 - 10.1093/jncics/pkaa046

DO - 10.1093/jncics/pkaa046

M3 - Journal article

C2 - 33134828

VL - 4

SP - pkaa046

JO - JNCI Cancer Spectrum

JF - JNCI Cancer Spectrum

SN - 2515-5091

IS - 5

ER -

ID: 61822439