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Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Gunnar Houen
  • Julie Heiden
  • Nicole H Trier
  • Anette H Draborg
  • Michael E Benros
  • Rūta Zinkevičiūtė
  • Rasa Petraitytė-Burneikienė
  • Evaldas Ciplys
  • Rimantas Slibinskas
  • Jette L Frederiksen
Vis graf over relationer

Antibody indices to Measles, Mumps, Varicella Zoster (MRZ) are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could be extended to increase diagnostic value. Samples from relapsing-remitting (RR) MS and optic neuritis (ON) patients were tested for reactivity to antigens from Epstein-Barr, Varicella Zoster, Measles, Mumps and Rubella (EMMRZ) viruses. Increased IgG levels in serum and cerebrospinal fluid (CSF) were found in RRMS patients, along with a significant correlation between serum and CSF. The sensitivity of the EMMRZ panel was increased approximately 40% compared to the MRZ panel, suggesting that the EMMRZ panel may be useful in MS and ON diagnostics.

OriginalsprogEngelsk
Artikelnummer577314
TidsskriftJournal of Neuroimmunology
Vol/bind346
Sider (fra-til)577314
ISSN0165-5728
DOI
StatusUdgivet - 2020

Bibliografisk note

Copyright © 2020 Elsevier B.V. All rights reserved.

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