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Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection - significance of macrolide treatment

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@article{fd52d63487fa436ba9adf8e81e6fb377,
title = "Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection - significance of macrolide treatment",
abstract = "Animal models of human diseases are invaluable and inevitable elements in identifying and testing novel treatments for serious diseases, including severe infections. Planning and conducting investigator-initiated human trials are generally accepted as being enormously challenging. In contrast, it is often underestimated how much planning, including background and modifying experiments, is needed to establish a relevant infectious disease animal model. However, representative animal infectious models, well designed to test generated hypotheses, are useful to improve our understanding of pathogenesis, virulence factors and host response and to identify novel treatment candidates and therapeutic strategies. Such results can subsequently proceed to clinical testing if suitable. The present review aims at presenting all the pulmonary Pseudomonas aeruginosa infectious models we have knowledge of and the detailed descriptions of established animal models in our laboratory focusing on macrolide therapy are presented.",
keywords = "Animal model, biofilm, chronic lung infection, cystic fibrosis, immunology, macrolide",
author = "Kim Thomsen and Osamu Kobayashi and Kenji Kishi and Ryo Shirai and {{\O}strup Jensen}, Peter and Arne Heydorn and Morten Hentzer and Henrik Calum and Lars Christophersen and Niels H{\o}iby and Claus Moser",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
month = jun,
day = "12",
doi = "10.1111/apm.13161",
language = "English",
pages = "1--19",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",

}

RIS

TY - JOUR

T1 - Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection - significance of macrolide treatment

AU - Thomsen, Kim

AU - Kobayashi, Osamu

AU - Kishi, Kenji

AU - Shirai, Ryo

AU - Østrup Jensen, Peter

AU - Heydorn, Arne

AU - Hentzer, Morten

AU - Calum, Henrik

AU - Christophersen, Lars

AU - Høiby, Niels

AU - Moser, Claus

N1 - This article is protected by copyright. All rights reserved.

PY - 2021/6/12

Y1 - 2021/6/12

N2 - Animal models of human diseases are invaluable and inevitable elements in identifying and testing novel treatments for serious diseases, including severe infections. Planning and conducting investigator-initiated human trials are generally accepted as being enormously challenging. In contrast, it is often underestimated how much planning, including background and modifying experiments, is needed to establish a relevant infectious disease animal model. However, representative animal infectious models, well designed to test generated hypotheses, are useful to improve our understanding of pathogenesis, virulence factors and host response and to identify novel treatment candidates and therapeutic strategies. Such results can subsequently proceed to clinical testing if suitable. The present review aims at presenting all the pulmonary Pseudomonas aeruginosa infectious models we have knowledge of and the detailed descriptions of established animal models in our laboratory focusing on macrolide therapy are presented.

AB - Animal models of human diseases are invaluable and inevitable elements in identifying and testing novel treatments for serious diseases, including severe infections. Planning and conducting investigator-initiated human trials are generally accepted as being enormously challenging. In contrast, it is often underestimated how much planning, including background and modifying experiments, is needed to establish a relevant infectious disease animal model. However, representative animal infectious models, well designed to test generated hypotheses, are useful to improve our understanding of pathogenesis, virulence factors and host response and to identify novel treatment candidates and therapeutic strategies. Such results can subsequently proceed to clinical testing if suitable. The present review aims at presenting all the pulmonary Pseudomonas aeruginosa infectious models we have knowledge of and the detailed descriptions of established animal models in our laboratory focusing on macrolide therapy are presented.

KW - Animal model

KW - biofilm

KW - chronic lung infection

KW - cystic fibrosis

KW - immunology

KW - macrolide

UR - http://www.scopus.com/inward/record.url?scp=85110940226&partnerID=8YFLogxK

U2 - 10.1111/apm.13161

DO - 10.1111/apm.13161

M3 - Review

C2 - 34117660

SP - 1

EP - 19

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

M1 - 13161

ER -

ID: 66308628