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Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity

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Gannon, Anne-Louise ; O'Hara, Laura ; Mason, Ian J ; Jørgensen, Anne ; Frederiksen, Hanne ; Curley, Michael ; Milne, Laura ; Smith, Sarah ; Mitchell, Rod T ; Smith, Lee B. / Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity. I: Frontiers in Endocrinology. 2021 ; Bind 11. s. 599869.

Bibtex

@article{fd370e6238394468ac5cc779e9caa4e4,
title = "Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity",
abstract = "Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in target tissues are well characterized, there is little research covering the role of androgen-signaling within the adrenal itself. Adrenal glands express AR which is essential for the regression of the X-zone in male mice. Female mice also undergo X-zone regression during their first pregnancy, however whether this is also controlled by AR signaling is unknown. To understand the role of the androgen receptor (AR) in the female adrenal, we utilized a Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.",
keywords = "adrenal cortex, androgen receptor, hyperplasia, spindle cell, X-zone",
author = "Anne-Louise Gannon and Laura O'Hara and Mason, {Ian J} and Anne J{\o}rgensen and Hanne Frederiksen and Michael Curley and Laura Milne and Sarah Smith and Mitchell, {Rod T} and Smith, {Lee B}",
note = "Copyright {\textcopyright} 2021 Gannon, O{\textquoteright}Hara, Mason, J{\o}rgensen, Frederiksen, Curley, Milne, Smith, Mitchell and Smith.",
year = "2021",
month = jan,
day = "21",
doi = "10.3389/fendo.2020.599869",
language = "English",
volume = "11",
pages = "599869",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity

AU - Gannon, Anne-Louise

AU - O'Hara, Laura

AU - Mason, Ian J

AU - Jørgensen, Anne

AU - Frederiksen, Hanne

AU - Curley, Michael

AU - Milne, Laura

AU - Smith, Sarah

AU - Mitchell, Rod T

AU - Smith, Lee B

N1 - Copyright © 2021 Gannon, O’Hara, Mason, Jørgensen, Frederiksen, Curley, Milne, Smith, Mitchell and Smith.

PY - 2021/1/21

Y1 - 2021/1/21

N2 - Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in target tissues are well characterized, there is little research covering the role of androgen-signaling within the adrenal itself. Adrenal glands express AR which is essential for the regression of the X-zone in male mice. Female mice also undergo X-zone regression during their first pregnancy, however whether this is also controlled by AR signaling is unknown. To understand the role of the androgen receptor (AR) in the female adrenal, we utilized a Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.

AB - Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in target tissues are well characterized, there is little research covering the role of androgen-signaling within the adrenal itself. Adrenal glands express AR which is essential for the regression of the X-zone in male mice. Female mice also undergo X-zone regression during their first pregnancy, however whether this is also controlled by AR signaling is unknown. To understand the role of the androgen receptor (AR) in the female adrenal, we utilized a Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.

KW - adrenal cortex

KW - androgen receptor

KW - hyperplasia

KW - spindle cell

KW - X-zone

UR - http://www.scopus.com/inward/record.url?scp=85100484625&partnerID=8YFLogxK

U2 - 10.3389/fendo.2020.599869

DO - 10.3389/fendo.2020.599869

M3 - Journal article

C2 - 33584538

VL - 11

SP - 599869

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 599869

ER -

ID: 62444514