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Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients

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Hvilsom, Gitte Bjørn ; Londero, Stefano Christian ; Hahn, Christoffer Holst ; Schytte, Sten ; Pedersen, Henrik Baymler ; Christiansen, Peer ; Kiss, Katalin ; Larsen, Stine Rosenkilde ; Jespersen, Marie Louise ; Lelkaitis, Giedrius ; Godballe, Christian. / Anaplastic thyroid carcinoma in Denmark 1996-2012 : A national prospective study of 219 patients. I: Cancer epidemiology. 2018 ; Bind 53. s. 65-71.

Bibtex

@article{58ba5e8687f94e8f99fa737df5154bf4,
title = "Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients",
abstract = "BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56{\%} of the patients had lymph node metastasis and 38{\%} distant metastasis. We observed one- and five-year survival of 20.7{\%} and 11.0{\%}, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds {"}respiratory impairment at diagnosis{"} and {"}introduction of a national fast track cancer program{"} to the list of already established prognostic indicators for ATC.",
author = "Hvilsom, {Gitte Bj{\o}rn} and Londero, {Stefano Christian} and Hahn, {Christoffer Holst} and Sten Schytte and Pedersen, {Henrik Baymler} and Peer Christiansen and Katalin Kiss and Larsen, {Stine Rosenkilde} and Jespersen, {Marie Louise} and Giedrius Lelkaitis and Christian Godballe",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = "4",
doi = "10.1016/j.canep.2018.01.011",
language = "English",
volume = "53",
pages = "65--71",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Anaplastic thyroid carcinoma in Denmark 1996-2012

T2 - A national prospective study of 219 patients

AU - Hvilsom, Gitte Bjørn

AU - Londero, Stefano Christian

AU - Hahn, Christoffer Holst

AU - Schytte, Sten

AU - Pedersen, Henrik Baymler

AU - Christiansen, Peer

AU - Kiss, Katalin

AU - Larsen, Stine Rosenkilde

AU - Jespersen, Marie Louise

AU - Lelkaitis, Giedrius

AU - Godballe, Christian

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/4

Y1 - 2018/4

N2 - BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.

AB - BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.

U2 - 10.1016/j.canep.2018.01.011

DO - 10.1016/j.canep.2018.01.011

M3 - Journal article

VL - 53

SP - 65

EP - 71

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

ER -

ID: 56133205