Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Analysis of HOXA9 methylated ctDNA in ovarian cancer using sense-antisense measurement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Reference values for leptin/adiponectin ratio in healthy children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Arg82Cys polymorphism of the protein Nepmucin implies a role in HDL metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Administration of whey protein complexed vitamin D3 to vitamin D3-deficient growing Sprague-Dawley rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Bone involvement in patients with spondyloarthropathies

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Harjit P Bhattoa
  • Etienne Cavalier
  • Richard Eastell
  • Annemieke C Heijboer
  • Niklas R Jørgensen
  • Konstantinos Makris
  • Candice Z Ulmer
  • John A Kanis
  • Cyrus Cooper
  • Stuart L Silverman
  • Samuel D Vasikaran
  • IFCC-IOF Committee for Bone Metabolism
Vis graf over relationer

Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.

OriginalsprogEngelsk
TidsskriftClinica chimica acta; international journal of clinical chemistry
Vol/bind515
Sider (fra-til)16-20
Antal sider5
ISSN0009-8981
DOI
StatusUdgivet - apr. 2021

ID: 64127535