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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Amyotrophic lateral sclerosis: The complement and inflammatory hypothesis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The ficolin response to LPS challenge in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Common and rare genetic variants of complement components in human disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Complement activation by cholesterol crystals triggers a subsequent cytokine response

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Mobilising patients with severe acquired brain injury in intensive care (MAWERIC) - Protocol for a randomised cross-over trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prevalence and duration of anti-SARS-CoV-2 antibodies in healthcare workers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Diagnostic criteria of CNS infection in patients with external ventricular drainage after traumatic brain injury: a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Humoral response to two doses of BNT162b2 vaccination in people with HIV

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Reliability of cerebral autoregulation using different measures of perfusion pressure in patients with subarachnoid hemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Amyotrophic lateral sclerosis (ALS) is a devastating, neurodegenerative motor neuron disease. The aetiology of ALS remains an enigma which hinders the design of an effective treatment to prevent, postpone, or reverse the pathophysiological changes occurring during the aggressive progression of this disease. During the last decade, basic research within the innate immune system, and in particular the complement system, has revealed new, important roles of the innate immune system during development, homeostasis, and ageing within as well as outside the central nervous system. Several lines of evidence indicate that aberrant activation of the complement system locally in the central nervous system as well as systemically may be involved in the pathophysiology of ALS. This exciting new knowledge could point towards the innate immune system as a potential target of medical intervention in ALS. Recently, the historic perception of ALS as a central neurodegenerative disease has been challenged due to the significant amount of evidence of a dying-back mechanism causing the selective destruction of the motor neurons, indicating that disease onset occurs outside the borders of the blood-brain-barrier. This review addresses the function of the innate immune system during ALS. We emphasize the role of the complement system and specifically suggest the involvement of ficolin-3 from the lectin pathway in the pathophysiology of ALS.

OriginalsprogEngelsk
TidsskriftMolecular Immunology
Vol/bind102
Sider (fra-til)14-25
Antal sider12
ISSN0161-5890
DOI
StatusUdgivet - okt. 2018

ID: 56257116