Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Altered body composition in male long-term survivors of paediatric allogeneic haematopoietic stem cell transplantation: impact of conditioning regimen, chronic graft-versus-host disease and hypogonadism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Possible Relevance of Soluble Luteinizing Hormone Receptor during Development and Adulthood in Boys and Men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. CPMS-improving patient care in Europe via virtual case discussions

    Publikation: Bidrag til tidsskriftReviewpeer review

  5. ENDO-ERN expert opinion on the differential diagnosis of pubertal delay

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Changes in body composition related to metabolic syndrome are frequent among survivors of haematopoietic stem cell transplantation (HSCT), but insights into predisposing factors are incomplete, and it is unknown to what degree these changes persist at long term. We cross-sectionally investigated body composition by dual-energy X-ray absorptiometry in 98 male survivors of paediatric allogeneic HSCT. Median (range) age at follow-up was 28.1 (18.5-47.0) years and median (range) time from transplant was 18.3 (7.7-34.6) years. Lean Body Mass Index and Skeletal Muscle Mass Index were lower in patients compared to the reference population (mean (SD) standard deviation score (SDS) -1.29 (0.99), p < 0.001 and -1.20 (1.03), p < 0.001). Fat Mass Index was comparable to the reference population, but android/gynoid (AG) fat ratio SDS was higher (mean (SD) 0.46 (1.28), p < 0.001). These changes were found in patients treated with total body irradiation (TBI) as well as non-TBI regimens, although most pronounced in the former. Further, low lean mass was associated with chronic graft-versus-host disease, while high AG ratio was associated with lower testosterone levels. Since the combination of low lean mass and high AG ratio increases the risk of cardio-metabolic disease, these health issues should be monitored at long-term clinical follow-up after paediatric HSCT.

OriginalsprogEngelsk
TidsskriftBone Marrow Transplantation
Vol/bind56
Udgave nummer2
Sider (fra-til)457-460
Antal sider4
ISSN0268-3369
DOI
StatusUdgivet - feb. 2021

ID: 61066442