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Alignment of Transcatheter Aortic-Valve Neo-Commissures (ALIGN TAVR): Impact on Final Valve Orientation and Coronary Artery Overlap

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DOI

  1. Transcatheter Treatment of Residual Significant Mitral Regurgitation Following TAVR: A Multicenter Registry

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  2. Redo-TAVR: What About the Coronary Arteries?

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  3. Telescopic Catheter Technique for Difficult Aortic Valve Crossing During TAVR

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  4. Coronary Access After TAVR-in-TAVR as Evaluated by Multidetector Computed Tomography

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  5. Patient-Specific Computer Simulation in TAVR With the Self-Expanding Evolut R Valve

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  • Gilbert H L Tang
  • Syed Zaid
  • Andreas Fuchs
  • Tsuyoshi Yamabe
  • Farhang Yazdchi
  • Eisha Gupta
  • Hasan Ahmad
  • Klaus F Kofoed
  • Joshua B Goldberg
  • Cenap Undemir
  • Ryan K Kaple
  • Pinak B Shah
  • Tsuyoshi Kaneko
  • Steven L Lansman
  • Sahil Khera
  • Jason C Kovacic
  • George D Dangas
  • Stamatios Lerakis
  • Samin K Sharma
  • Annapoorna Kini
  • David H Adams
  • Omar K Khalique
  • Rebecca T Hahn
  • Lars Søndergaard
  • Isaac George
  • Susheel K Kodali
  • Ole De Backer
  • Martin B Leon
  • Vinayak N Bapat
Vis graf over relationer

Objectives: The aim of this study was to evaluate the impact of initial deployment orientation of SAPIEN 3, Evolut, and ACURATE-neo transcatheter heart valves on their final orientation and neocommissural overlap with coronary arteries. Background: Coronary artery access and redo transcatheter aortic valve replacement (TAVR) following initial TAVR may be influenced by transcatheter heart valve orientation. In this study the impact of transcatheter heart valve deployment orientation on commissural alignment was evaluated. Methods: Pre-TAVR computed tomography and procedural fluoroscopy were analyzed in 828 patients who underwent TAVR (483 SAPIEN 3, 245 Evolut, and 100 ACURATE-neo valves) from March 2016 to September 2019 at 5 centers. Coplanar fluoroscopic views were coregistered to pre-TAVR computed tomography to determine commissural alignment. Severe overlap between neocommissural posts and coronary arteries was defined as 0° to 20° apart. The SAPIEN 3 had 1 commissural post crimped at 3, 6, 9, and 12 o'clock. The Evolut “Hat” marker and ACURATE-neo commissural post at deployment were classified as center back (CB), inner curve (IC), outer curve (OC), or center front (CF) and matched with final orientation. Results: Initial SAPIEN 3 crimped orientation had no impact on commissural alignment. Evolut “Hat” at OC or CF at initial deployment had less severe overlap than IC or CB (p < 0.001) against the left main (15.7% vs. 66.0%) and right coronary (7.1% vs. 51.1%) arteries. Tracking Evolut “Hat” at OC of the descending aorta (n = 107) improved OC at deployment from 70.2% to 91.6% (p = 0.002) and reduced coronary artery overlap by 36% to 60% (p < 0.05). ACURATE-neo commissural post at CB or IC during deployment had less coronary artery overlap compared to CF or OC (p < 0.001), with intentional alignment successful in 5 of 7 cases. Conclusions: This is the first systematic evaluation of commissural alignment in TAVR. More than 30% to 50% of cases had overlap with 1 or both coronary arteries. Initial SAPIEN 3 orientation had no impact on alignment, but specific initial orientations of Evolut and ACURATE improved alignment. Optimizing valve alignment to avoid coronary artery overlap will be important in coronary artery access and redo TAVR.

OriginalsprogEngelsk
TidsskriftJACC: Cardiovascular Interventions
Vol/bind13
Udgave nummer9
Sider (fra-til)1030-1042
Antal sider13
ISSN1936-8798
DOI
StatusUdgivet - 11 maj 2020

Bibliografisk note

Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

ID: 61823873