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Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium

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Li, H, Terry, MB, Antoniou, AC, Phillips, K-A, Kast, K, Mooij, TM, Engel, C, Noguès, C, Stoppa-Lyonnet, D, Lasset, C, Berthet, P, Mari, V, Caron, O, Barrowdale, D, Frost, D, Brewer, C, Evans, DG, Izatt, L, Side, L, Walker, L, Tischkowitz, M, Rogers, MT, Porteous, ME, Meijers-Heijboer, HEJ, Gille, JJ, Blok, MJ, Hoogerbrugge, N, Daly, MB, Andrulis, IL, Buys, SS, John, EM, McLachlan, S-A, Friedlander, M, Tan, YY, Osorio, A, Caldes, T, Jakubowska, A, Simard, J, Singer, CF, Olah, E, Navratilova, M, Foretova, L, Gerdes, A-M, Roos-Blom, M-J, Arver, B, Olsson, H, Schmutzler, RK, Hopper, JL, Milne, RL, Easton, DF & The BRCA1 and BRCA2 Cohort Consortium 2020, 'Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, bind 29, nr. 2, s. 368-378. https://doi.org/10.1158/1055-9965.EPI-19-0546

APA

Li, H., Terry, M. B., Antoniou, A. C., Phillips, K-A., Kast, K., Mooij, T. M., Engel, C., Noguès, C., Stoppa-Lyonnet, D., Lasset, C., Berthet, P., Mari, V., Caron, O., Barrowdale, D., Frost, D., Brewer, C., Evans, D. G., Izatt, L., Side, L., ... The BRCA1 and BRCA2 Cohort Consortium (2020). Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(2), 368-378. https://doi.org/10.1158/1055-9965.EPI-19-0546

CBE

Li H, Terry MB, Antoniou AC, Phillips K-A, Kast K, Mooij TM, Engel C, Noguès C, Stoppa-Lyonnet D, Lasset C, Berthet P, Mari V, Caron O, Barrowdale D, Frost D, Brewer C, Evans DG, Izatt L, Side L, Walker L, Tischkowitz M, Rogers MT, Porteous ME, Meijers-Heijboer HEJ, Gille JJ, Blok MJ, Hoogerbrugge N, Daly MB, Andrulis IL, Buys SS, John EM, McLachlan S-A, Friedlander M, Tan YY, Osorio A, Caldes T, Jakubowska A, Simard J, Singer CF, Olah E, Navratilova M, Foretova L, Gerdes A-M, Roos-Blom M-J, Arver B, Olsson H, Schmutzler RK, Hopper JL, Milne RL, Easton DF, The BRCA1 and BRCA2 Cohort Consortium. 2020. Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 29(2):368-378. https://doi.org/10.1158/1055-9965.EPI-19-0546

MLA

Vancouver

Author

Li, Hongyan ; Terry, Mary Beth ; Antoniou, Antonis C ; Phillips, Kelly-Anne ; Kast, Karin ; Mooij, Thea M ; Engel, Christoph ; Noguès, Catherine ; Stoppa-Lyonnet, Dominique ; Lasset, Christine ; Berthet, Pascaline ; Mari, Veronique ; Caron, Olivier ; Barrowdale, Daniel ; Frost, Debra ; Brewer, Carole ; Evans, D Gareth ; Izatt, Louise ; Side, Lucy ; Walker, Lisa ; Tischkowitz, Marc ; Rogers, Mark T ; Porteous, Mary E ; Meijers-Heijboer, Hanne E J ; Gille, Johan Jp ; Blok, Marinus J ; Hoogerbrugge, Nicoline ; Daly, Mary B ; Andrulis, Irene L ; Buys, Saundra S ; John, Esther M ; McLachlan, Sue-Anne ; Friedlander, Michael ; Tan, Yen Y ; Osorio, Ana ; Caldes, Trinidad ; Jakubowska, Anna ; Simard, Jacques ; Singer, Christian F ; Olah, Edith ; Navratilova, Marie ; Foretova, Lenka ; Gerdes, Anne-Marie ; Roos-Blom, Marie-José ; Arver, Brita ; Olsson, Håkan ; Schmutzler, Rita K ; Hopper, John L ; Milne, Roger L ; Easton, Douglas F ; The BRCA1 and BRCA2 Cohort Consortium. / Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers : results from The BRCA1 and BRCA2 Cohort Consortium. I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2020 ; Bind 29, Nr. 2. s. 368-378.

Bibtex

@article{0ba82c959f354ef3a3d6ed52b24aa010,
title = "Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium",
abstract = "BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer (BC), but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high BC risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with BC risk is essential.METHODS: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers; 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers; 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.RESULTS: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 (95%CI:1.02,1.39) and the HR from prospective analysis (HRP) was 1.36 (95%CI:0.99,1.87). For BRCA2 mutation carriers, smoking for more than five years before a FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR=1.25,95%CI:1.01,1.55 and HRP=1.30,95%CI:0.83,2.01). For both carrier groups, alcohol consumption was not associated with BC risk.CONCLUSIONS: The finding that smoking during the pre-reproductive years increases BC risk for mutation carriers warrants further investigation.IMPACT: This is the largest prospective study of BRCA mutation carriers to assess these important risk factors.",
author = "Hongyan Li and Terry, {Mary Beth} and Antoniou, {Antonis C} and Kelly-Anne Phillips and Karin Kast and Mooij, {Thea M} and Christoph Engel and Catherine Nogu{\`e}s and Dominique Stoppa-Lyonnet and Christine Lasset and Pascaline Berthet and Veronique Mari and Olivier Caron and Daniel Barrowdale and Debra Frost and Carole Brewer and Evans, {D Gareth} and Louise Izatt and Lucy Side and Lisa Walker and Marc Tischkowitz and Rogers, {Mark T} and Porteous, {Mary E} and Meijers-Heijboer, {Hanne E J} and Gille, {Johan Jp} and Blok, {Marinus J} and Nicoline Hoogerbrugge and Daly, {Mary B} and Andrulis, {Irene L} and Buys, {Saundra S} and John, {Esther M} and Sue-Anne McLachlan and Michael Friedlander and Tan, {Yen Y} and Ana Osorio and Trinidad Caldes and Anna Jakubowska and Jacques Simard and Singer, {Christian F} and Edith Olah and Marie Navratilova and Lenka Foretova and Anne-Marie Gerdes and Marie-Jos{\'e} Roos-Blom and Brita Arver and H{\aa}kan Olsson and Schmutzler, {Rita K} and Hopper, {John L} and Milne, {Roger L} and Easton, {Douglas F} and {The BRCA1 and BRCA2 Cohort Consortium}",
note = "{\textcopyright}2019 American Association for Cancer Research.",
year = "2020",
month = feb,
day = "1",
doi = "10.1158/1055-9965.EPI-19-0546",
language = "English",
volume = "29",
pages = "368--378",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",
number = "2",

}

RIS

TY - JOUR

T1 - Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers

T2 - results from The BRCA1 and BRCA2 Cohort Consortium

AU - Li, Hongyan

AU - Terry, Mary Beth

AU - Antoniou, Antonis C

AU - Phillips, Kelly-Anne

AU - Kast, Karin

AU - Mooij, Thea M

AU - Engel, Christoph

AU - Noguès, Catherine

AU - Stoppa-Lyonnet, Dominique

AU - Lasset, Christine

AU - Berthet, Pascaline

AU - Mari, Veronique

AU - Caron, Olivier

AU - Barrowdale, Daniel

AU - Frost, Debra

AU - Brewer, Carole

AU - Evans, D Gareth

AU - Izatt, Louise

AU - Side, Lucy

AU - Walker, Lisa

AU - Tischkowitz, Marc

AU - Rogers, Mark T

AU - Porteous, Mary E

AU - Meijers-Heijboer, Hanne E J

AU - Gille, Johan Jp

AU - Blok, Marinus J

AU - Hoogerbrugge, Nicoline

AU - Daly, Mary B

AU - Andrulis, Irene L

AU - Buys, Saundra S

AU - John, Esther M

AU - McLachlan, Sue-Anne

AU - Friedlander, Michael

AU - Tan, Yen Y

AU - Osorio, Ana

AU - Caldes, Trinidad

AU - Jakubowska, Anna

AU - Simard, Jacques

AU - Singer, Christian F

AU - Olah, Edith

AU - Navratilova, Marie

AU - Foretova, Lenka

AU - Gerdes, Anne-Marie

AU - Roos-Blom, Marie-José

AU - Arver, Brita

AU - Olsson, Håkan

AU - Schmutzler, Rita K

AU - Hopper, John L

AU - Milne, Roger L

AU - Easton, Douglas F

AU - The BRCA1 and BRCA2 Cohort Consortium

N1 - ©2019 American Association for Cancer Research.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer (BC), but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high BC risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with BC risk is essential.METHODS: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers; 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers; 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.RESULTS: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 (95%CI:1.02,1.39) and the HR from prospective analysis (HRP) was 1.36 (95%CI:0.99,1.87). For BRCA2 mutation carriers, smoking for more than five years before a FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR=1.25,95%CI:1.01,1.55 and HRP=1.30,95%CI:0.83,2.01). For both carrier groups, alcohol consumption was not associated with BC risk.CONCLUSIONS: The finding that smoking during the pre-reproductive years increases BC risk for mutation carriers warrants further investigation.IMPACT: This is the largest prospective study of BRCA mutation carriers to assess these important risk factors.

AB - BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer (BC), but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high BC risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with BC risk is essential.METHODS: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers; 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers; 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.RESULTS: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 (95%CI:1.02,1.39) and the HR from prospective analysis (HRP) was 1.36 (95%CI:0.99,1.87). For BRCA2 mutation carriers, smoking for more than five years before a FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR=1.25,95%CI:1.01,1.55 and HRP=1.30,95%CI:0.83,2.01). For both carrier groups, alcohol consumption was not associated with BC risk.CONCLUSIONS: The finding that smoking during the pre-reproductive years increases BC risk for mutation carriers warrants further investigation.IMPACT: This is the largest prospective study of BRCA mutation carriers to assess these important risk factors.

U2 - 10.1158/1055-9965.EPI-19-0546

DO - 10.1158/1055-9965.EPI-19-0546

M3 - Journal article

C2 - 31792088

VL - 29

SP - 368

EP - 378

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 2

ER -

ID: 58956622