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Aggressive multiple sclerosis (2): Treatment

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@article{43acae327e014371b81eefed226cb5a0,
title = "Aggressive multiple sclerosis (2): Treatment",
abstract = "The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.",
keywords = "Aggressive, highly active, multiple sclerosis, disability, relapsing-remitting, treatment response",
author = "Georgina Arrambide and Ellen Iacobaeus and Amato, {Maria Pia} and Tobias Derfuss and Sandra Vukusic and Bernhard Hemmer and Lou Brundin and Mar Tintore and {2018 ECTRIMS Focused Workshop Group} and Frederiksen, {Jette Lautrup Battistini} and S{\o}rensen, {Per Soelberg}",
year = "2020",
month = jun,
day = "12",
doi = "10.1177/1352458520924595",
language = "English",
volume = "26",
pages = "1045--1063",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "Sage Science Press (UK)",
number = "9",

}

RIS

TY - JOUR

T1 - Aggressive multiple sclerosis (2)

T2 - Treatment

AU - Arrambide, Georgina

AU - Iacobaeus, Ellen

AU - Amato, Maria Pia

AU - Derfuss, Tobias

AU - Vukusic, Sandra

AU - Hemmer, Bernhard

AU - Brundin, Lou

AU - Tintore, Mar

AU - 2018 ECTRIMS Focused Workshop Group

A2 - Frederiksen, Jette Lautrup Battistini

A2 - Sørensen, Per Soelberg

PY - 2020/6/12

Y1 - 2020/6/12

N2 - The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.

AB - The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.

KW - Aggressive

KW - highly active

KW - multiple sclerosis

KW - disability

KW - relapsing-remitting

KW - treatment response

U2 - 10.1177/1352458520924595

DO - 10.1177/1352458520924595

M3 - Review

C2 - 32530366

VL - 26

SP - 1045

EP - 1063

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 9

ER -

ID: 61515402