Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sex Disparities in Sudden Cardiac Death

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Familial Evaluation in Idiopathic Ventricular Fibrillation: Diagnostic Yield and Significance of J-Wave Syndromes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Right Ventricular Dysfunction and the Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Comparing Seizure-Related Death and Suicide in Younger Adults with Epilepsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hjertestop hos en patient med langt QT-syndrom i androgendeprivationsterapi

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nationwide burden of sudden cardiac death: A study of 54,028 deaths in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Sudden unexpected death in epilepsy in persons younger than 50 years: A retrospective nationwide cohort study in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Anat Milman
  • Antoine Andorin
  • Jean-Baptiste Gourraud
  • Frederic Sacher
  • Philippe Mabo
  • Sung-Hwan Kim
  • Shingo Maeda
  • Yoshihide Takahashi
  • Tsukasa Kamakura
  • Takeshi Aiba
  • Giulio Conte
  • Jimmy J M Juang
  • Eran Leshem
  • Michael Rahkovich
  • Aviram Hochstadt
  • Yuka Mizusawa
  • Pieter G Postema
  • Elena Arbelo
  • Zhengrong Huang
  • Isabelle Denjoy
  • Carla Giustetto
  • Yanushi D Wijeyeratne
  • Carlo Napolitano
  • Yoav Michowitz
  • Ramon Brugada
  • Ruben Casado-Arroyo
  • Jean Champagne
  • Leonardo Calo
  • Georgia Sarquella-Brugada
  • Jacob Tfelt-Hansen
  • Silvia G Priori
  • Masahiko Takagi
  • Christian Veltmann
  • Pietro Delise
  • Domenico Corrado
  • Elijah R Behr
  • Fiorenzo Gaita
  • Gan-Xin Yan
  • Josep Brugada
  • Antoine Leenhardt
  • Arthur A M Wilde
  • Pedro Brugada
  • Kengo F Kusano
  • Kenzo Hirao
  • Gi-Byoung Nam
  • Vincent Probst
  • Bernard Belhassen
Vis graf over relationer

BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.

METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).

CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

OriginalsprogEngelsk
TidsskriftCirculation: Arrhythmia and Electrophysiology
Vol/bind10
Udgave nummer12
Sider (fra-til)e005222
ISSN1941-3149
DOI
StatusUdgivet - dec. 2017

ID: 52685916