Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital

Adverse reaction after hyaluronan injection for minimally invasive papilla volume augmentation. A report on two cases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Drugs and diseases: Summary and consensus statements of group 1. The 5th EAO Consensus Conference 2018

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The effect of antiresorptive drugs on implant therapy: Systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Implant Therapy in the Esthetic Zone

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

  2. Strategies for Treatment of Tooth Loss after Trauma to the Anterior Region of Young Patients

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

  • Kristina Bertl
  • Klaus Gotfredsen
  • Simon S Jensen
  • Corinna Bruckmann
  • Andreas Stavropoulos
Vis graf over relationer

OBJECTIVES: To report two cases of adverse reaction after mucosal hyaluronan (HY) injection around implant-supported crowns, with the aim to augment the missing interdental papilla.

MATERIAL AND METHODS: Two patients with single, non-neighbouring, implants in the anterior maxilla, who were treated within the frames of a randomized controlled clinical trial testing the effectiveness of HY gel injection to reconstruct missing papilla volume at single implants, presented an adverse reaction. Injection of HY was performed bilaterally using a 3-step technique: (i) creation of a reservoir in the mucosa directly above the mucogingival junction, (ii) injection into the attached gingiva/mucosa below the missing papilla, and (iii) injection 2-3 mm apically to the papilla tip. The whole-injection session was repeated once after approximately 4 weeks.

RESULTS: Both patients presented with swelling and extreme tenderness with a burning sensation on the lip next to the injection area, after the second injection session. In one of the cases, a net-like skin discoloration (livedo reticularis) was also noted. The symptoms lasted for up to 7 days, and in both cases, symptoms resolved without any signs of skin or mucosal necrosis or any permanent damage.

CONCLUSION: Most likely, water attraction over time by the highly hygroscopic HY, exerted progressively an external vascular compression and at least partial occlusion of neighbouring blood vessels. An infection or an allergic reaction seems unlikely, since all symptoms gradually disappeared within a week irrespective use of antimicrobials, while an allergic reaction most likely would not have been restricted to one side.

TidsskriftClinical Oral Implants Research
Udgave nummer7
Sider (fra-til)871-876
Antal sider6
StatusUdgivet - jul. 2017

ID: 52736260