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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Adjuvanted HLA-supertype restricted subdominant peptides induce new T-cell immunity during untreated HIV-1-infection

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Ingrid Karlsson
  • Lea Brandt
  • Lasse Vinner
  • Ingrid Kromann
  • Lars Vibe Andreasen
  • Peter Andersen
  • Jan Gerstoft
  • Gitte Kronborg
  • Anders Fomsgaard
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We investigated the potential of inducing additional T-cell immunity during chronic HIV-1 infection directed to subdominant HIV-1 epitopes from common HLA-supertypes. Ten treatment-naïve HIV-1-infected individuals were immunized with peptides in the adjuvant CAF01. One individual received placebo. T-cell immunogenicity was examined longitudinally by a flow cytometry (CD107a, IFNγ, TNFα, IL-2 and/or MIP1β expression) as well as IFNγ ELISPOT. Safety was evaluated by clinical follow up combined with monitoring of biochemistry, hematology, CD4 T-cell counts and viral load. New CD4 and CD8 T-cell responses specific for one or more vaccine epitopes were induced in 10/10 vaccinees. The responses were dominated by CD107a and MIP1β expression. There were no significant changes in HIV-1 viral load or CD4 T-cell counts. Our study demonstrates that the peptide/CAF01 vaccine is safe and that it is possible to generate new HIV-1 T-cell responses to defined epitopes in treatment-naïve HIV-1-infected individuals.
OriginalsprogEngelsk
TidsskriftClinical immunology (Orlando, Fla.)
Vol/bind146
Udgave nummer2
Sider (fra-til)120-30
Antal sider11
ISSN1521-6616
DOI
StatusUdgivet - feb. 2013

ID: 40879869