Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. High specificity but low sensitivity of mutation-specific antibodies against EGFR mutations in non-small-cell lung cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The morphological growth patterns of colorectal liver metastases are prognostic for overall survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Frequent hypermethylation of DBC1 in malignant lymphoproliferative neoplasms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Inverted papilloma of the conjunctiva

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Adherence to preventive swallowing exercises for head and neck cancer patients undergoing (chemo)radiotherapy treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Periocular necrotizing soft tissue infection in Greater Copenhagen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Adenoid cystic carcinoma is among the most frequent malignancies in the salivary and lacrimal glands and has a grave prognosis characterized by frequent local recurrences, distant metastases, and tumor-related mortality. Conversely, adenoid cystic carcinoma of the breast is a rare type of triple-negative (estrogen and progesterone receptor, HER2) and basal-like carcinoma, which in contrast to other triple-negative and basal-like breast carcinomas has a very favorable prognosis. Irrespective of site, adenoid cystic carcinoma is characterized by gene fusions involving MYB, MYBL1, and NFIB, and the reason for the different clinical outcomes is unknown. In order to identify the molecular mechanisms underlying the discrepancy in clinical outcome, we characterized the phenotypic profiles, pattern of gene rearrangements, and global microRNA expression profiles of 64 salivary gland, 9 lacrimal gland, and 11 breast adenoid cystic carcinomas. All breast and lacrimal gland adenoid cystic carcinomas had triple-negative and basal-like phenotypes, while salivary gland tumors were indeterminate in 13% of cases. Aberrations in MYB and/or NFIB were found in the majority of cases in all three locations, whereas MYBL1 involvement was restricted to tumors in the salivary gland. Global microRNA expression profiling separated salivary and lacrimal gland adenoid cystic carcinoma from their respective normal glands but could not distinguish normal breast adenoid cystic carcinoma from normal breast tissue. Hierarchical clustering separated adenoid cystic carcinomas of salivary gland origin from those of the breast and placed lacrimal gland carcinomas in between these. Functional annotation of the microRNAs differentially expressed between salivary gland and breast adenoid cystic carcinoma showed these as regulating genes involved in metabolism, signal transduction, and genes involved in other cancers. In conclusion, microRNA dysregulation is the first class of molecules separating adenoid cystic carcinoma according to the site of origin. This highlights a novel venue for exploring the biology of adenoid cystic carcinoma.

OriginalsprogEngelsk
TidsskriftModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Vol/bind31
Udgave nummer8
Sider (fra-til)1211-1225
Antal sider15
ISSN0893-3952
DOI
StatusUdgivet - aug. 2018

ID: 56360395