Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Acute social defeat does not alter cerebral 5-HT2A receptor binding in male Wistar rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Similar serotonin-2A receptor binding in rats with different coping styles or levels of aggression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Transient activation of mTOR following forced treadmill exercise in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Direct comparison of [(18) F]MH.MZ and [(18) F]altanserin for 5-HT(2A) receptor imaging with PET

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. No change in [¹¹C]CUMI-101 binding to 5-HT(1A) receptors after intravenous citalopram in human

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Reward processing in major depressive disorder and prediction of treatment response - Neuropharm study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

It has been hypothesized that effects of uncontrollable stress on serotonin receptor expression contribute to the etiology of stress-related disorders like depression. While the serotonin-2A receptors (5-HT2A R) are thought to be important in this context, only few studies examined effects of stress on this receptor subtype. In this study, we therefore assessed acute and long-term changes in 5HT2A R binding after social defeat stress in rats. Male Wistar rats were subjected to social defeat by placing them in the home cage of an aggressive, dominant Long Evans rat. Acute social defeat suppressed growth, but did not affect anxiety-like behavior in an open field test. A positron emission tomography scan with the 5-HT2A R tracer [11C]MDL 100907 1 day and 3 weeks after defeat did not show significant changes in receptor binding. To verify these results, [3H]MDL 100907 binding assays were performed in homogenates of prefrontal cortex and hippocampus, which also did not indicate any changes in Bmax or Kd . These findings do not support the hypothesis that changes in 5-HT2A R function are a vital mechanism through which uncontrollable stress contributes to stress-related pathologies such as depression. It remains to be determined whether effects of stress on 5HT2A R binding depend on the nature of the stressor or on the characteristics of the rat strain.

OriginalsprogEngelsk
TidsskriftSynapse (New York, N.Y.)
Vol/bind68
Udgave nummer9
Sider (fra-til)379-86
Antal sider8
ISSN0887-4476
DOI
StatusUdgivet - sep. 2014

ID: 44558333