Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
A small group of children with acute lymphoblastic leukemia (ALL) have a preleukemic phase of pancytopenia followed by a period of spontaneous remission before the diagnosis (pre-ALL). A 6-year-old girl presented with pancytopenia, fever, and myelodysplasia. Following transient remission pre-B ALL was diagnosed 14 months later. Clonal B-lineage blasts at the period of pancytopenia were identified retrospectively. The interval between pre-ALL and ALL-diagnosis was longer than previously reported. The infection was clinically severe and might have induced a significant endogenous corticosteroids production resulting in the long-lasting remission. The case supports the adrenal and the Coley's toxin hypothesis in leukemogenesis.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Pediatric Hematology / Oncology |
Vol/bind | 38 |
Udgave nummer | 8 |
Sider (fra-til) | e271-e273 |
ISSN | 1077-4114 |
DOI | |
Status | Udgivet - nov. 2016 |
ID: 49162140