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Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

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Vestergaard, ET, Zubanovic, NB, Rittig, N, Møller, N, Kuhre, RE, Holst, JJ, Rehfeld, JF & Thomsen, HH 2021, 'Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men', Diabetes, Obesity and Metabolism, bind 23, nr. 8, s. 1834-1842. https://doi.org/10.1111/dom.14402

APA

Vestergaard, E. T., Zubanovic, N. B., Rittig, N., Møller, N., Kuhre, R. E., Holst, J. J., Rehfeld, J. F., & Thomsen, H. H. (2021). Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men. Diabetes, Obesity and Metabolism, 23(8), 1834-1842. https://doi.org/10.1111/dom.14402

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MLA

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Author

Vestergaard, Esben Thyssen ; Zubanovic, Natasa Brkovic ; Rittig, Nikolaj ; Møller, Niels ; Kuhre, Rune Ehrenreich ; Holst, Jens J ; Rehfeld, Jens F ; Thomsen, Henrik Holm. / Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men. I: Diabetes, Obesity and Metabolism. 2021 ; Bind 23, Nr. 8. s. 1834-1842.

Bibtex

@article{29e28e5a17564597b0f726004a493a28,
title = "Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men",
abstract = "AIM: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration.METHODS: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 along with appetite sensation scores assessed by visual analogue scale.RESULTS: KE ingestion resulted in an average peak beta-hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were -52.1 (-79.4, -24.8) for KE and -48.4 (-75.4, -21.5) pg/mL for GLU intake (P < .01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP-1, GIP, gastrin and cholecystokinin were not affected by KE ingestion.CONCLUSION: Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP-1.",
keywords = "appetite control, clinical trial, dietary intervention, GLP-1, randomized trial, clinical trial, GLP-1, randomized trial, appetite control, dietary intervention",
author = "Vestergaard, {Esben Thyssen} and Zubanovic, {Natasa Brkovic} and Nikolaj Rittig and Niels M{\o}ller and Kuhre, {Rune Ehrenreich} and Holst, {Jens J} and Rehfeld, {Jens F} and Thomsen, {Henrik Holm}",
note = "{\textcopyright} 2021 John Wiley & Sons Ltd.",
year = "2021",
month = aug,
doi = "10.1111/dom.14402",
language = "English",
volume = "23",
pages = "1834--1842",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

AU - Vestergaard, Esben Thyssen

AU - Zubanovic, Natasa Brkovic

AU - Rittig, Nikolaj

AU - Møller, Niels

AU - Kuhre, Rune Ehrenreich

AU - Holst, Jens J

AU - Rehfeld, Jens F

AU - Thomsen, Henrik Holm

N1 - © 2021 John Wiley & Sons Ltd.

PY - 2021/8

Y1 - 2021/8

N2 - AIM: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration.METHODS: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 along with appetite sensation scores assessed by visual analogue scale.RESULTS: KE ingestion resulted in an average peak beta-hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were -52.1 (-79.4, -24.8) for KE and -48.4 (-75.4, -21.5) pg/mL for GLU intake (P < .01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP-1, GIP, gastrin and cholecystokinin were not affected by KE ingestion.CONCLUSION: Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP-1.

AB - AIM: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration.METHODS: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 along with appetite sensation scores assessed by visual analogue scale.RESULTS: KE ingestion resulted in an average peak beta-hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were -52.1 (-79.4, -24.8) for KE and -48.4 (-75.4, -21.5) pg/mL for GLU intake (P < .01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP-1, GIP, gastrin and cholecystokinin were not affected by KE ingestion.CONCLUSION: Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP-1.

KW - appetite control, clinical trial, dietary intervention, GLP-1, randomized trial

KW - clinical trial

KW - GLP-1

KW - randomized trial

KW - appetite control

KW - dietary intervention

UR - http://www.scopus.com/inward/record.url?scp=85105135289&partnerID=8YFLogxK

U2 - 10.1111/dom.14402

DO - 10.1111/dom.14402

M3 - Journal article

C2 - 33852195

VL - 23

SP - 1834

EP - 1842

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 8

ER -

ID: 66793404