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Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study

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Heldarskard, Gerda Ferja ; Spangmose, Anne Lærke ; Henningsen, Anna-Karina Aaris ; Wiingreen, Rikke ; Mortensen, Erik Lykke ; Gundersen, Tina Wullum ; Jensen, Rikke Beck ; Knorr, Sine ; Damm, Peter ; Forman, Julie Lyng ; Pinborg, Anja ; Clausen, Tine Dalsgaard. / Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study. I: The Journal of clinical endocrinology and metabolism. 2021 ; Bind 106, Nr. 11. s. e4554-e4564.

Bibtex

@article{af2874af460542f0bf37054518135818,
title = "Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study",
abstract = "CONTEXT: The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.OBJECTIVE: We assessed academic performance by grade point average (GPA) in children aged 15 to 16 years at compulsory school graduation, comparing offspring exposed to GDM (O-GDM) with offspring from the background population (O-BP).METHODS: This register-based, cohort study comprised all singletons born in Denmark between 1994 and 2001 (O-GDM: n = 4286; O-BP: n = 501 045). Standardized and internationally comparable GPAs were compared in univariate and multivariable linear models. Main outcome measures included the adjusted mean difference in GPA. We also analyzed the probability of having a high GPA, a GPA below passing, and no GPA registered.RESULTS: O-GDM had a GPA of 6.29 (SD 2.52), whereas O-BP had a GPA of 6.78 (SD 2.50). The adjusted mean difference was -0.36 (95% CI, -0.44 to -0.29), corresponding to a Cohen's D of 0.14. O-GDM had a lower probability of obtaining a high GPA (adjusted odds ratio [aOR] 0.68; 95% CI, 0.59 to 0.79), while their risk of obtaining a GPA below passing was similar to O-BP (aOR 1.20; 95% CI, 0.96 to 1.50). O-GDM had a higher risk of not having a GPA registered (aOR 1.38; 95% CI, 1.24 to 1.53).CONCLUSION: Academic performance in O-GDM was marginally lower than in O-BP. However, this difference is unlikely to be of clinical importance.",
author = "Heldarskard, {Gerda Ferja} and Spangmose, {Anne L{\ae}rke} and Henningsen, {Anna-Karina Aaris} and Rikke Wiingreen and Mortensen, {Erik Lykke} and Gundersen, {Tina Wullum} and Jensen, {Rikke Beck} and Sine Knorr and Peter Damm and Forman, {Julie Lyng} and Anja Pinborg and Clausen, {Tine Dalsgaard}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.",
year = "2021",
month = oct,
day = "21",
doi = "10.1210/clinem/dgab451",
language = "English",
volume = "106",
pages = "e4554--e4564",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "11",

}

RIS

TY - JOUR

T1 - Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study

AU - Heldarskard, Gerda Ferja

AU - Spangmose, Anne Lærke

AU - Henningsen, Anna-Karina Aaris

AU - Wiingreen, Rikke

AU - Mortensen, Erik Lykke

AU - Gundersen, Tina Wullum

AU - Jensen, Rikke Beck

AU - Knorr, Sine

AU - Damm, Peter

AU - Forman, Julie Lyng

AU - Pinborg, Anja

AU - Clausen, Tine Dalsgaard

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

PY - 2021/10/21

Y1 - 2021/10/21

N2 - CONTEXT: The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.OBJECTIVE: We assessed academic performance by grade point average (GPA) in children aged 15 to 16 years at compulsory school graduation, comparing offspring exposed to GDM (O-GDM) with offspring from the background population (O-BP).METHODS: This register-based, cohort study comprised all singletons born in Denmark between 1994 and 2001 (O-GDM: n = 4286; O-BP: n = 501 045). Standardized and internationally comparable GPAs were compared in univariate and multivariable linear models. Main outcome measures included the adjusted mean difference in GPA. We also analyzed the probability of having a high GPA, a GPA below passing, and no GPA registered.RESULTS: O-GDM had a GPA of 6.29 (SD 2.52), whereas O-BP had a GPA of 6.78 (SD 2.50). The adjusted mean difference was -0.36 (95% CI, -0.44 to -0.29), corresponding to a Cohen's D of 0.14. O-GDM had a lower probability of obtaining a high GPA (adjusted odds ratio [aOR] 0.68; 95% CI, 0.59 to 0.79), while their risk of obtaining a GPA below passing was similar to O-BP (aOR 1.20; 95% CI, 0.96 to 1.50). O-GDM had a higher risk of not having a GPA registered (aOR 1.38; 95% CI, 1.24 to 1.53).CONCLUSION: Academic performance in O-GDM was marginally lower than in O-BP. However, this difference is unlikely to be of clinical importance.

AB - CONTEXT: The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.OBJECTIVE: We assessed academic performance by grade point average (GPA) in children aged 15 to 16 years at compulsory school graduation, comparing offspring exposed to GDM (O-GDM) with offspring from the background population (O-BP).METHODS: This register-based, cohort study comprised all singletons born in Denmark between 1994 and 2001 (O-GDM: n = 4286; O-BP: n = 501 045). Standardized and internationally comparable GPAs were compared in univariate and multivariable linear models. Main outcome measures included the adjusted mean difference in GPA. We also analyzed the probability of having a high GPA, a GPA below passing, and no GPA registered.RESULTS: O-GDM had a GPA of 6.29 (SD 2.52), whereas O-BP had a GPA of 6.78 (SD 2.50). The adjusted mean difference was -0.36 (95% CI, -0.44 to -0.29), corresponding to a Cohen's D of 0.14. O-GDM had a lower probability of obtaining a high GPA (adjusted odds ratio [aOR] 0.68; 95% CI, 0.59 to 0.79), while their risk of obtaining a GPA below passing was similar to O-BP (aOR 1.20; 95% CI, 0.96 to 1.50). O-GDM had a higher risk of not having a GPA registered (aOR 1.38; 95% CI, 1.24 to 1.53).CONCLUSION: Academic performance in O-GDM was marginally lower than in O-BP. However, this difference is unlikely to be of clinical importance.

UR - http://www.scopus.com/inward/record.url?scp=85115977647&partnerID=8YFLogxK

U2 - 10.1210/clinem/dgab451

DO - 10.1210/clinem/dgab451

M3 - Journal article

C2 - 34156463

VL - 106

SP - e4554-e4564

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -

ID: 66575773