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ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors

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Vasan, SK, Hwang, J, Rostgaard, K, Nyrén, O, Ullum, H, Pedersen, OBV, Erikstrup, C, Melbye, M, Hjalgrim, H, Pawitan, Y & Edgren, G 2016, 'ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors' Cancer epidemiology, bind 44, s. 40-43. https://doi.org/10.1016/j.canep.2016.06.005

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Vasan, Senthil K ; Hwang, Jinseub ; Rostgaard, Klaus ; Nyrén, Olof ; Ullum, Henrik ; Pedersen, Ole B V ; Erikstrup, Christian ; Melbye, Mads ; Hjalgrim, Henrik ; Pawitan, Yudi ; Edgren, Gustaf. / ABO blood group and risk of cancer : A register-based cohort study of 1.6 million blood donors. I: Cancer epidemiology. 2016 ; Bind 44. s. 40-43.

Bibtex

@article{0eaedba83acd4be89f7628742977077c,
title = "ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors",
abstract = "INTRODUCTION: The associations between ABO blood group and cancer risk have been studied repeatedly, but results have been variable. Consistent associations have only been reported for pancreatic and gastric cancers.MATERIALS AND METHODS: We estimated associations between different ABO blood groups and site-specific cancer risk in a large cohort of healthy blood donors from Sweden and Denmark.RESULTS: A total of 1.6 million donors were followed over 27 million person-years (20 million in Sweden and 7 million in Denmark). We observed 119,584 cancer cases. Blood groups A, AB and B were associated either with increased or decreased risk of cancer at 13 anatomical sites (p≤0.05), compared to blood group O. Consistent with assessment using a false discovery rate approach, significant associations with ABO blood group were observed for cancer of the pancreas, breast, and upper gastrointestinal tract (mouth, salivary glands, pharynx, esophageal adenocarcinoma and stomach).DISCUSSION: Our study reconfirms the association between ABO blood group and cancer risk and exact underlying mechanisms involved needs further research.",
author = "Vasan, {Senthil K} and Jinseub Hwang and Klaus Rostgaard and Olof Nyr{\'e}n and Henrik Ullum and Pedersen, {Ole B V} and Christian Erikstrup and Mads Melbye and Henrik Hjalgrim and Yudi Pawitan and Gustaf Edgren",
note = "Copyright {\circledC} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = "10",
doi = "10.1016/j.canep.2016.06.005",
language = "English",
volume = "44",
pages = "40--43",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - ABO blood group and risk of cancer

T2 - A register-based cohort study of 1.6 million blood donors

AU - Vasan, Senthil K

AU - Hwang, Jinseub

AU - Rostgaard, Klaus

AU - Nyrén, Olof

AU - Ullum, Henrik

AU - Pedersen, Ole B V

AU - Erikstrup, Christian

AU - Melbye, Mads

AU - Hjalgrim, Henrik

AU - Pawitan, Yudi

AU - Edgren, Gustaf

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - INTRODUCTION: The associations between ABO blood group and cancer risk have been studied repeatedly, but results have been variable. Consistent associations have only been reported for pancreatic and gastric cancers.MATERIALS AND METHODS: We estimated associations between different ABO blood groups and site-specific cancer risk in a large cohort of healthy blood donors from Sweden and Denmark.RESULTS: A total of 1.6 million donors were followed over 27 million person-years (20 million in Sweden and 7 million in Denmark). We observed 119,584 cancer cases. Blood groups A, AB and B were associated either with increased or decreased risk of cancer at 13 anatomical sites (p≤0.05), compared to blood group O. Consistent with assessment using a false discovery rate approach, significant associations with ABO blood group were observed for cancer of the pancreas, breast, and upper gastrointestinal tract (mouth, salivary glands, pharynx, esophageal adenocarcinoma and stomach).DISCUSSION: Our study reconfirms the association between ABO blood group and cancer risk and exact underlying mechanisms involved needs further research.

AB - INTRODUCTION: The associations between ABO blood group and cancer risk have been studied repeatedly, but results have been variable. Consistent associations have only been reported for pancreatic and gastric cancers.MATERIALS AND METHODS: We estimated associations between different ABO blood groups and site-specific cancer risk in a large cohort of healthy blood donors from Sweden and Denmark.RESULTS: A total of 1.6 million donors were followed over 27 million person-years (20 million in Sweden and 7 million in Denmark). We observed 119,584 cancer cases. Blood groups A, AB and B were associated either with increased or decreased risk of cancer at 13 anatomical sites (p≤0.05), compared to blood group O. Consistent with assessment using a false discovery rate approach, significant associations with ABO blood group were observed for cancer of the pancreas, breast, and upper gastrointestinal tract (mouth, salivary glands, pharynx, esophageal adenocarcinoma and stomach).DISCUSSION: Our study reconfirms the association between ABO blood group and cancer risk and exact underlying mechanisms involved needs further research.

U2 - 10.1016/j.canep.2016.06.005

DO - 10.1016/j.canep.2016.06.005

M3 - Journal article

VL - 44

SP - 40

EP - 43

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

ER -

ID: 49163190