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A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma-a case report

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DOI

  1. Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Fluorescein-guided resection of cerebral metastases is associated with greater tumor resection

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  3. Right temporal lobe epilepsy surgery activates suppressed post-traumatic stress disorder 31 years after a robbery

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  4. Proposal of a new grading system for meningioma resection: the Copenhagen Protocol

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  5. Burr hole craniostomy versus minicraniotomy in chronic subdural hematoma: a comparative cohort study

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  1. Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Deep learning for Dixon MRI-based attenuation correction in PET/MRI of head and neck cancer patients

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Vis graf over relationer

Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.

OriginalsprogEngelsk
TidsskriftActa Neurochirurgica
Vol/bind164
Udgave nummer1
Sider (fra-til)267-271
Antal sider5
ISSN0001-6268
DOI
StatusUdgivet - jan. 2022

Bibliografisk note

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

ID: 68903815