Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital

A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures: A validation of interview data

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Trends in thyroid cancer: Retrospective analysis of incidence and survival in Denmark 1980-2014

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Danielle Vienneau
  • Denis Infanger
  • Maria Feychting
  • Joachim Schüz
  • Lisbeth Samsø Schmidt
  • Aslak Harbo Poulsen
  • Giorgio Tettamanti
  • Lars Klæboe
  • Claudia E Kuehni
  • Tore Tynes
  • Nicolas Von der Weid
  • Birgitta Lannering
  • Martin Röösli
Vis graf over relationer

Little is known about the aetiology of childhood brain tumours. We investigated anthropometric factors (birth weight, length, maternal age), birth characteristics (e.g. vacuum extraction, preterm delivery, birth order) and exposures during pregnancy (e.g. maternal: smoking, working, dietary supplement intake) in relation to risk of brain tumour diagnosis among 7-19 year olds. The multinational case-control study in Denmark, Sweden, Norway and Switzerland (CEFALO) included interviews with 352 (participation rate=83.2%) eligible cases and 646 (71.1%) population-based controls. Interview data were complemented with data from birth registries and validated by assessing agreement (Cohen's Kappa). We used conditional logistic regression models matched on age, sex and geographical region (adjusted for maternal age and parental education) to explore associations between birth factors and childhood brain tumour risk. Agreement between interview and birth registry data ranged from moderate (Kappa=0.54; worked during pregnancy) to almost perfect (Kappa=0.98; birth weight). Neither anthropogenic factors nor birth characteristics were associated with childhood brain tumour risk. Maternal vitamin intake during pregnancy was indicative of a protective effect (OR 0.75, 95%-CI: 0.56-1.01). No association was seen for maternal smoking during pregnancy or working during pregnancy. We found little evidence that the considered birth factors were related to brain tumour risk among children and adolescents.

TidsskriftCancer epidemiology
Sider (fra-til)52-9
Antal sider8
StatusUdgivet - feb. 2016

ID: 49839402