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Udgivet

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

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DOI

  1. Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

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  3. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

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  5. Neuromedin U does not act as a decretin in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Human brown adipose tissue (BAT) has been detected in adults but was recently suggested to be of brite/beige origin. We collected BAT from the supraclavicular region in 21 patients undergoing surgery for suspected cancer in the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26. A similar mRNA expression profile was observed when comparing isolated human adipocytes from BAT and white adipose tissue (WAT) depots, differentiated in vitro. In conclusion, our data suggest that human BAT might consist of both classical brown and recruitable brite adipocytes, an observation important for future considerations on how to induce human BAT.
OriginalsprogEngelsk
TidsskriftCell Metabolism
Vol/bind17
Udgave nummer5
Sider (fra-til)798-805
Antal sider8
ISSN1550-4131
DOI
StatusUdgivet - 7 maj 2013

ID: 38677010