Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

A∂- and not C-Fibers Mediate Thermal Hyperalgesia to Short Laser Stimuli After Burn Injury in Man

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neck pain and headache after whiplash injury: a systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. CACNG2 polymorphisms associate with chronic pain following mastectomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Postoperative pain, analgesia, and recovery-bedfellows that cannot be ignored

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Heterozygous Mutations in Gtp-Cyclohydrolase-1 Reduce Bh4 Biosynthesis but Not Pain Sensitivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

It remains unclear which nerve fibers are responsible for mediating hyperalgesia following skin injury. Here, we examined the role of A∂- and C-fibers in inflammatory hyperalgesia following a first-degree burn injury. A CO2-laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg, to stimulate selectively the relatively fast conducting thinly myelinated A∂ and the slowly conducting unmyelinated C-fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ- and C-fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1- and 24-hours post-injury. First-degree burn injury caused a significant decrease in Aδ-fiber detection thresholds and a significant increase in the proportion of Aδ-fiber mediated responses in the inflamed area 24 hours, but not 1 hour, following burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber mediated sensations were observed. Our findings indicate that quickly-adapting Aδ-fibers but not quickly-adapting C-fibers are sensitized when activated by short and ultra-fast heat stimuli following skin burn injury. Our results further show that this change occurs between 1- and 24-hours post-injury and that it does not extend to the skin surrounding the injury.

OriginalsprogEngelsk
TidsskriftPain
Vol/bind159
Udgave nummer11
Sider (fra-til)2331-2338
Antal sider8
ISSN0304-3959
DOI
StatusUdgivet - 2018

ID: 54756155