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Rigshospitalet - en del af Københavns Universitetshospital
Lars Edvinsson

Lars Edvinsson

Professor

Rigshospitalet Glostrup, Nordstjernevej 42

Bygning: Forskerparken

2600 Glostrup

Danmark

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Lars Edvinsson

Professor

  • Klinisk Eksperimentel Forskningsafdeling GLO
Besøgsadresse:
Rigshospitalet Glostrup, Nordstjernevej 42
Forskerparken
2600
Glostrup
Danmark

E-mail: lars.edvinsson@regionh.dk

Areas of Expertise

Professor Edvinsson is leading expert in the field of cerebral circulation. He is world-recognized for his work on vascular innervation and receptor regulation. His extensive research has been a major contributor to what is known about the roles of the cerebral vasculature in health and diseases such as stroke and primary headaches. He has been a pioneer in elucidating the function of neuropeptides in the vascular system and a key player in the research and development of CGRP blockers for treatment of migraine. Professor Edvinsson also has a strong clinical background as a clinical pharmacologist and an MD in internal medicine.

Method Expertise: Immunohistochemistry, qPCR, Western blot, molecular biology of cell signaling, mRNA arrays, proteomics, cell and organ cultures, animal models for acute stroke and acute myocardial infarcts, pharmacology and treatment methods, string myography and perfusion myography for receptor and functional studies of isolated blood vessels.

Education/Training

University of Lund, Sweden
1975 DMSci
1980 M.D.
1985 Specialist in Clinical Pharmacology
1988 Specialist in Internal Medicine

Positions and Employment

University of Copenhagen, Denmark
2007-ongoing Director and founder, Glostrup Research Institute, Copenhagen University Hospital
1997-ongoing Chairman, Dept. Experimental Clinical Research, Glostrup Research Institute
2011-2016 Director, Center of Excellence in Stroke Research (supported by Lundbeck Foundation), Copenhagen University, Glostrup Research Institute
2008-ongoing Professor in Receptor Regulation in Cerebrovascular and Cardiovascular Diseases, Faculty of Health and Medical Sciences
University of Lund, Sweden
2002-ongoing Professor in Internal Medicine, Faculty of Medicine
1985- Director, Experimental Vascular Research Laboratory, Biomedical Center
1988- Specialist in Internal Medicine, Lund University Hospital
2009-ongoing Member, Human Ethics Committee
1996-2002 Associate Professor in Internal Medicine
1988-1996 Lecturer, University of Lund
1983-2003 Vice-Chair, Member, Animal Ethics Committee, Lund University
Adjunct Positions
2004- Adjunct Professor, Basic and Translational Research Institute, Xian University, Xian, China
1990- Adjunct Professor in Pharmacology, Southern Illinois University, Illinois, USA
1990-1995 Professor II in Neuroscience (20%), Trondheim University, Norway

Honors and Awards

2014-2016 Elected Trustee and Director, International Headache Society
2013- Member, Steering Board, European Headache Federation
2012 Lifetime Achievement Award, American Headache Society
2012 Honorary Doctorate, University of Szeged, Hungary
2008-2011 Bland Lane International Distinguished Professor Award, FAMRI, USA
2002-` Honorary Fellow, British Pharmacology Society
1985- Honorary Fellow, Stroke Council, American Heart Association

Professional Recognition

Over the last 3 decades, Dr. Edvinsson has been invited yearly to international congresses and meetings as well as to universities worldwide to give lectures and keynote presentations. Most recently, he was recognized by American headache leaders with a Lifetime Achievement Award for Research (Boston, 2012).
Received an Honorary Doctorate from Szeged University, Hungary (2012) and at Xián University, China (2013).

•Over 1000 peer-reviewed research publications. 
•128 book chapters.
•Over 100 international scientific lectures as invited/key-note speaker.
•Member scientific society boards and organizer of symposia and meetings throughout career.

Research Management and Team Leader Experience

I started as a team leader in 1976 with my first PhD students. In 1980 I got my first laboratory at the University Hospital in Lund which was supported by the Swedish Research Council and the Heart and Lung Foundation. This was expanded in 1985 to several laboratories and offices located at the Experimental Department, Lund University. In 1988 the laboratory relocated to Lund University Hospital and then it moved to the Biomedical Center when it opened in 2000; this is my current laboratory in Lund. In parallel I was responsible for organizing and building the Glostrup Research Park in Copenhagen which opened under my leadership in 2007.

Student Mentoring

1978- Supervisor for 52 PhD and 20 Masters Students (graduated) and 8 PhD and 4 Masters Students (in progress) at University of Copenhagen and University of Lund.
Evaluator of over 20 Masters, PhD and DMSci theses in Denmark and internationally
Supervisor for over 25 postdoctoral students from Denmark and recruited internationally (Sweden, England, Scotland, France, Hungary, USA, Canada, Mexico, Chile, Japan, China, Pakistan, India)

Grant Awards

Research projects and student support have been continuously funded since 1975.
Current research and student support at Glostrup Research Institute funded by grants from the Danish Medical Research Council; Danish Agency for Science, Technology and Innovation; The Lundbeck Foundation with two major grants (the LUCENS group 2005-2014; Center of Excellence in Stroke 2011-2016), EU, and the Novo Nordisk Foundation.

Bibliometry

H-index = 81
Citations in total = 32.804 (2019)
Citations latest 10 years per year = 1000/year
Articles in total = More than 1000

Publications

Does inflammation have a role in migraine?

Edvinsson, L., Haanes, K. A. & Warfvinge, K., aug. 2019, I : Nature reviews. Neurology. 15, 8, s. 483-490 8 s.

The changing faces of migraine

Martelletti, P., Ashina, M. & Edvinsson, L., 10 maj 2019, I : The Journal of Headache and Pain Online. 20, 1, s. 52 2 s., 52.

Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache

Rapoport, A. M. & Edvinsson, L., maj 2019, I : Neurological Sciences. 40, Suppl 1, s. 75-80 6 s.

CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior

Filiz, A., Tepe, N., Eftekhari, S., Boran, H. E., Dilekoz, E., Edvinsson, L. & Bolay, H., 1 mar. 2019, I : Cephalalgia : an international journal of headache. 39, 3, s. 354-365 12 s.

Board Walk - July 2019

Edvinsson, L., 2019, I : Cephalalgia : an international journal of headache. 39, 8, s. 1067-1068 2 s.

Discovery of CGRP in relation to migraine

Edvinsson, L. & Goadsby, P. J., 2019, I : Cephalalgia : an international journal of headache. 39, 3, s. 331-332 2 s.

Distribution of CGRP and CGRP receptor components in the rat brain

Warfvinge, K. & Edvinsson, L., 2019, I : Cephalalgia : an international journal of headache. 39, 3, s. 342-353 12 s.

Exploration of purinergic receptors as potential anti-migraine targets using established pre-clinical migraine models

Haanes, K. A., Labastida-Ramírez, A., Blixt, F. W., Rubio-Beltrán, E., Dirven, C. M., Danser, A. H., Edvinsson, L. & MaassenVanDenBrink, A., 2019, I : Cephalalgia : an international journal of headache. s. 333102419851810

MEK/ERK/1/2 sensitive vascular changes coincide with retinal functional deficit, following transient ophthalmic artery occlusion

Blixt, F. W., Haanes, K. A., Ohlsson, L., Dreisig, K., Fedulov, V., Warfvinge, K. & Edvinsson, L., 2019, I : Experimental Eye Research. 179, s. 142-149 8 s.

MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats

Christensen, S. T., Johansson, S. E., Radziwon-Balicka, A., Warfvinge, K., Haanes, K. A. & Edvinsson, L., 2019, I : PLoS One. 14, 4, s. e0215398 e0215398.

Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets

Haanes, K. A. & Edvinsson, L., 2019, I : CNS Drugs. 33, 6, s. 525-537 13 s.

Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches

Frederiksen, S. D., Haanes, K. A., Warfvinge, K. & Edvinsson, L., 2019, I : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 39, 4, s. 610-632 23 s.

Recognizing the role of CGRP and CGRP receptors in migraine and its treatment

Edvinsson, L. & Warfvinge, K., 2019, I : Cephalalgia : an international journal of headache. 39, 3, s. 366-373 8 s.

Role of CGRP in Migraine

Edvinsson, L., 2019, Handbook of Experimental Pharmacology. s. epub (Handbook of Experimental Pharmacology).

Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)

Martelletti, P., Edvinsson, L. & Ashina, M., 2019, I : The Journal of Headache and Pain Online. 20, 1, s. 60 3 s.

Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model

Christensen, S. T., Grell, A. S., Johansson, S. E., Andersson, C. M., Edvinsson, L. & Haanes, K. A., 2019, I : Drug Delivery . 26, 1, s. 680-688 9 s.

Vascular pathology of large cerebral arteries in experimental subarachnoid hemorrhage: Vasoconstriction, functional CGRP depletion and maintained CGRP sensitivity

Johansson, S. E., Abdolalizadeh, B., Sheykhzade, M., Edvinsson, L. & Sams, A., 2019, I : European Journal of Pharmacology. 846, s. 109-118 10 s.

PACAP38 and PAC receptor blockade: a new target for headache?

European Headache Federation School of Advanced Studies (EHF-SAS), Rubio-Beltrán, E., Correnti, E., Deen, M., Kamm, K., Kelderman, T., Papetti, L., Vigneri, S., MaassenVanDenBrink, A. & Edvinsson, L., 7 aug. 2018, I : Journal of Headache and Pain. 19, 1, s. 64 11 s.

Headache advances in 2017: a new horizon in migraine therapy

Edvinsson, L., jan. 2018, I : The Lancet Neurology. 17, 1, s. 5-6 2 s.

Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging

Mostajeran, M., Wetterling, F., W Blixt, F., Edvinsson, L. & Ansar, S., 2018, I : Acta Physiologica (Online). 223, 1, s. e12985

CGRP Antibodies as Prophylaxis in Migraine

Edvinsson, L., 2018, I : Cell. 175, 7, s. 1719

CGRP as the target of new migraine therapies - successful translation from bench to clinic

Edvinsson, L., Haanes, K. A., Warfvinge, K. & Krause, D. N., 2018, I : Nature reviews. Neurology. 14, 6, s. 338-350 13 s.

Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans

Frederiksen, S. D., Warfvinge, K., Ohlsson, L. & Edvinsson, L., 2018, I : Neuroscience. 393, s. 319-332 14 s.

Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Ohlsson, L., Kronvall, E., Stratton, J. & Edvinsson, L., 2018, I : Journal of Headache and Pain. 19, 1, s. 66 6 s.

Increased endothelin-1-mediated vasoconstriction after organ culture in rat and pig ocular arteries can be suppressed with MEK/ERK1/2 inhibitors

W Blixt, F., Kristian Haanes, A., Ohlsson, L., Christiansen, A. T., Warfvinge, K. & Edvinsson, L., 2018, I : Acta Ophthalmologica. 96, 5, s. e619-e625

PAC1 receptor mRNA and protein distribution in rat and human trigeminal and sphenopalatine ganglia, spinal trigeminal nucleus and in dura mater

Hensley, K., Pretorius, J., Chan, B., Page, K., Liu, H., Choi, C., Shi, D., Xu, C., Edvinsson, L. & Miller, S., 2018, I : Cephalalgia : an international journal of headache. s. 333102418821621

PACAP and its role in primary headaches

Edvinsson, L., Tajti, J., Szalárdy, L. & Vécsei, L., 2018, I : Journal of Headache and Pain. 19, 1, s. 21

Role of Pannexin and adenosine triphosphate (ATP) following myocardial ischemia/reperfusion

Kristiansen, S. B., Skovsted, G. F., Berchtold, L. A., Radziwon-Balicka, A., Dreisig, K., Edvinsson, L., Sheykhzade, M. & Haanes, K. A., 2018, I : Scandinavian cardiovascular journal : SCJ. 52, 6, s. 340-343 4 s.

Smoking and Endothelial Dysfunction

Golbidi, S., Edvinsson, L. & Laher, I., 2018, I : Current Vascular Pharmacology.

The CGRP Pathway in Migraine as a Viable Target for Therapies

Edvinsson, L., 2018, I : Headache. 58 Suppl 1, s. 33-47 15 s.

The therapeutic impact of new migraine discoveries

Vécsei, L., Lukács, M., Tajti, J., Fülöp, F., Toldi, J. & Edvinsson, L., 2018, I : Current Medicinal Chemistry.

Vancouver Declaration on Global Headache Patient Advocacy 2018

Dodick, D., Edvinsson, L., Makino, T., Grisold, W., Sakai, F., Jensen, R., Balch, A., Ruiz de la Torre, E., Henscheid-Lorenz, D., Craven, A. & Ashina, M., 2018, I : Cephalalgia. 38, 13, s. 1899-1909

Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

Sheykhzade, M., Abdolalizadeh, B., Koole, C., Pickering, D. S., Dreisig, K., Johansson, S. E., Abboud, B. K., Dreier, R., Berg, J. O., Jeppesen, J. L., Sexton, P. M., Edvinsson, L., Wootten, D. & Sams, A., 2018, I : European Journal of Pharmacology. 829, s. 85-92 8 s.

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca(2+) levels in the perfused and non-perfused isolated rat middle cerebral artery

Erdling, A., Sheykhzade, M. & Edvinsson, L., dec. 2017, I : Journal of Headache and Pain. 18, 1, s. 61

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

Lukács, M., Warfvinge, K., Tajti, J., Fülöp, F., Toldi, J., Vecsei, L. & Edvinsson, L., dec. 2017, I : Journal of Headache and Pain. 18, 1, s. 39

Blocking CGRP in migraine patients - a review of pros and cons

Deen, M., Correnti, E., Kamm, K., Kelderman, T., Papetti, L., Rubio-Beltrán, E., Vigneri, S., Edvinsson, L., Maassen Van Den Brink, A. & European Headache Federation School of Advanced Studies (EHF-SAS), 25 sep. 2017, I : Journal of Headache and Pain. 18, 1, s. 96

Migraine associated with altitude: results from a population-based study in Nepal

Linde, M., Edvinsson, L., Manandhar, K., Risal, A. & Steiner, T. J., aug. 2017, I : European Journal of Neurology. 24, 8, s. 1055-1061 7 s.

Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway

Müller, A. H., Edwards, A. V. G., Larsen, M. R., Nielsen, J., Warfvinge, K., Povlsen, G. K. & Edvinsson, L., aug. 2017, I : Journal of Molecular Neuroscience. 62, 3-4, s. 380-394 15 s.

The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine

Edvinsson, L., maj 2017, I : Headache. 57 Suppl 2, s. 47-55 9 s.

Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries

Sheykhzade, M., Amandi, N., Pla, M. V., Abdolalizadeh, B., Sams, A., Warfvinge, K., Edvinsson, L. & Pickering, D. S., mar. 2017, I : Vascular Pharmacology. 90, s. 36-43 8 s.

A novel multicolor flow-cytometry application for quantitative detection of receptors on vascular smooth muscle cells

Radziwon-Balicka, A., Degn, M., Johansson, S. E., Warfvinge, K. & Edvinsson, L., 2017, I : P L o S One. 12, 10, s. e0186504

Alterations in the Cerebral Microvascular Proteome Expression Profile After Transient Global Cerebral Ischemia in Rat

Spray, S., Johansson, S. E., Edwards, A. V. G., Larsen, M. R., Radziwon-Balicka, A. I., Povlsen, G. K. & Edvinsson, L., 2017, I : Journal of Molecular Neuroscience. 61, 3, s. 396-411

Board Walk - October 2017

Edvinsson, L., 2017, I : Cephalalgia : an international journal of headache. 37, 11, s. 1111-1112 2 s.

Cerebrovascular gene expression in spontaneously hypertensive rats

Grell, A-S., Frederiksen, S. D., Edvinsson, L. & Ansar, S., 2017, I : P L o S One. 12, 9, s. e0184233

Cerebrovascular Gene Expression in Spontaneously Hypertensive Rats After Transient Middle Cerebral Artery Occlusion

Grell, A-S., Mostajeran, M., Frederiksen, S. D., Edvinsson, L. & Ansar, S., 2017, I : Neuroscience. 367, s. 219-232 14 s.

Changes in vasodilation following myocardial ischemia/reperfusion in rats

Kristiansen, S. B., Sheykhzade, M., Edvinsson, L. & Haanes, K. A., 2017, I : Nitric Oxide: Biology and Chemistry. 70, s. 68-75 8 s.

Contractile Responses in Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion

Grell, A-S., Mostajeran, M., Edvinsson, L. & Ansar, S., 2017, I : Pharmacology. 101, 3-4, s. 120-132

Distribution of CGRP and its receptor components CLR and RAMP1 in the rat retina

Blixt, F. W., Radziwon-Balicka, A., Edvinsson, L. & Warfvinge, K., 2017, I : Experimental Eye Research. 161, s. 124-131

Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery

Zhang, Y., Mi, M., Xie, Y-H., Wang, S-W., Edvinsson, L. & Xu, C-B., 2017, I : Advances in Pharmacological Sciences. 2017, s. 6507048

Endothelin receptor mediated Ca(2+) signaling in coronary arteries after experimentally induced ischemia/reperfusion injury in rat

Kristiansen, S. B., Haanes, K. A., Sheykhzade, M. & Edvinsson, L., 2017, I : Journal of Molecular and Cellular Cardiology. 111, s. 1-9 9 s.

Enhanced contractility of intraparenchymal arterioles after global cerebral ischemia in rat - new insights into the development of delayed cerebral hypoperfusion

Spray, S., Johansson, S. E., Radziwon-Balicka, A., Haanes, K. A., Warfvinge, K., Povlsen, G. K., Kelly, P. A. T. & Edvinsson, L., 2017, I : Acta physiologica (Oxford, England). 220, 4, s. 417-431

Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats

Mostajeran, M., Edvinsson, L., Warfvinge, K., Singh, R. & Ansar, S., 2017, I : Acta Physiologica. 219, 4, s. 814-824 11 s.

Lipid-soluble Cigarette Smoke Particles Induced Vascular Endothelin Type A Receptor Up-Regulation through Activation of ERK1/2 Signal Pathways

Zhang, Y., Zhang, W., Edvinsson, L. & Xu, C-B., 2017, I : Basic & clinical pharmacology & toxicology. 120, 4, s. 327-334

Migraine, neurogenic inflammation, drug development - pharmacochemical aspects

Lukács, M., Tajti, J., Fülöp, F., Toldi, J., Edvinsson, L. & Vécsei, L., 2017, I : Current Medicinal Chemistry. 24, 33, s. 3649-3665

Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat

Skovsted, G. F., Kruse, L. S., Berchtold, L. A., Grell, A-S., Warfvinge, K. & Edvinsson, L., 2017, I : P L o S One. 12, 3, s. e0174119

Perivascular Neurotransmitter Regulation of Cerebral Blood Flow

Edvinsson, L., 2017, Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc, s. 70-74 5 s.

Expression of messenger molecules and receptors in rat and human sphenopalatine ganglion indicating therapeutic targets

Steinberg, A., Frederiksen, S. D., Blixt, F. W., Warfvinge, K. & Edvinsson, L., dec. 2016, I : Journal of Headache and Pain. 17, 1, s. 78

KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion

Lukács, M., Warfvinge, K., Kruse, L. S., Tajti, J., Fülöp, F., Toldi, J., Vécsei, L. & Edvinsson, L., dec. 2016, I : Journal of Headache and Pain. 17, 1, s. 64

Release of PACAP-38 in episodic cluster headache patients - an exploratory study

Tuka, B., Szabó, N., Tóth, E., Kincses, Z. T., Párdutz, Á., Szok, D., Körtési, T., Bagoly, T., Helyes, Z., Edvinsson, L., Vécsei, L. & Tajti, J., dec. 2016, I : Journal of Headache and Pain. 17, 1, s. 69

The effects of MEK1/2 inhibition on cigarette smoke exposure-induced ET receptor upregulation in rat cerebral arteries

Cao, L., Ping, N-N., Cao, Y-X., Li, W., Cai, Y., Warfvinge, K. & Edvinsson, L., 1 aug. 2016, I : Toxicology and Applied Pharmacology. 304, s. 70-8 9 s.

Characterization of Relaxant Responses to Natriuretic Peptides in the Human Microcirculation In Vitro and In Vivo

Edvinsson, M-L., Ahnstedt, H., Edvinsson, L. & Andersson, S. E., aug. 2016, I : Microcirculation Review. 23, 6, s. 438-46 9 s.

Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies

Miller, S., Liu, H., Warfvinge, K., Shi, L., Dovlatyan, M., Xu, C. & Edvinsson, L., 22 jul. 2016, I : Neuroscience. 328, s. 165-83 19 s.

Improved assessment of outcomes following transient global cerebral ischemia in mice

Spray, S. & Edvinsson, L., jul. 2016, I : Experimental Brain Research. 234, 7, s. 1925-34

Reduced Mechanical Stretch Induces Enhanced Endothelin B Receptor-Mediated Contractility via Activation of Focal Adhesion Kinase and Extracellular Regulated Kinase 1/2 in Cerebral Arteries from Rat

Spray, S., Rasmussen, M. N. P., Skovsted, G. F., Warfvinge, K., Sheykhzade, M. & Edvinsson, L., jul. 2016, I : Basic & clinical pharmacology & toxicology. 119, 1, s. 68-77 10 s.

Enhanced Endothelin-1 Mediated Vasoconstriction of the Ophthalmic Artery May Exacerbate Retinal Damage after Transient Global Cerebral Ischemia in Rat

Blixt, F. W., Johansson, S. E., Johnson, L., Haanes, K. A., Warfvinge, K. & Edvinsson, L., 20 jun. 2016, I : P L o S One. 11, 6, s. e0157669

Mapping the calcitonin receptor in human brain stem

Bower, R. L., Eftekhari, S., Waldvogel, H. J., Faull, R. L. M., Tajti, J., Edvinsson, L., Hay, D. L. & Walker, C. S., 1 maj 2016, I : A J P: Regulatory, Integrative and Comparative Physiology (Online). 310, 9, s. R788-93

Contractile Changes in the Vasculature After Subchronic Smoking: A Comparison Between Wild Type and Surfactant Protein D Knock-Out Mice

Haanes, K. A., Kruse, L. S., Wulf-Johansson, H., Stottrup, C. C., Sorensen, G. L. & Edvinsson, L., maj 2016, I : Nicotine & Tobacco Research. 18, 5, s. 642-6 5 s., ntv136.

Similar Adiponectin Levels in Obese Normotensive and Obese Hypertensive Men and No Vasorelaxant Effect of Adiponectin on Human Arteries

Dreier, R., Asferg, C., Berg, J. O., Andersen, U. B., Flyvbjerg, A., Frystyk, J., Linneberg, A., Jeppesen, J. L., Edvinsson, L. & Skovsted, G. F., feb. 2016, I : Basic & clinical pharmacology & toxicology. 118, 2, s. 128-135

New insights on pyrimidine signalling within the arterial vasculature - Different roles for P2Y2 and P2Y6 receptors in large and small coronary arteries of the mouse

Haanes, K. A., Spray, S., Syberg, S., Jørgensen, N. R., Robaye, B., Boeynaems, J-M. & Edvinsson, L., 28 jan. 2016, I : Journal of Molecular and Cellular Cardiology. 93, s. 1-11 11 s.

Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography

Eftekhari, S., Gaspar, R. C., Roberts, R., Chen, T-B., Zeng, Z., Villarreal, S., Edvinsson, L. & Salvatore, C. A., 1 jan. 2016, I : The Journal of comparative neurology. 524, 1, s. 90-118 29 s.

European Headache Federation consensus on technical investigation for primary headache disorders

Mitsikostas, D. D., Ashina, M., Craven, A., Diener, H. C., Goadsby, P. J., Ferrari, M. D., Lampl, C., Paemeleire, K., Pascual, J., Siva, A., Olesen, J., Osipova, V., Martelletti, P., EHF committee (Lars Edvinsson, members) & Edvinsson, L., 2016, I : Journal of Headache and Pain. 17, s. 5

Peripheral Sensory Neurons Expressing Melanopsin Respond to Light

Matynia, A., Nguyen, E., Sun, X., Blixt, F. W., Parikh, S., Kessler, J., Pérez de Sevilla Müller, L., Habib, S., Kim, P., Wang, Z. Z., Rodriguez, A., Charles, A., Nusinowitz, S., Edvinsson, L., Barnes, S., Brecha, N. C. & Gorin, M. B., 2016, I : Frontiers in Neural Circuits. 10, s. 60

Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage

Lundblad, C., Haanes, K. A., Grände, G. & Edvinsson, L., dec. 2015, I : The Journal of Headache and Pain Online. 16, 1, s. 91

Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries

Skovsted, G. F., Kilic, S. & Edvinsson, L., nov. 2015, I : Basic & clinical pharmacology & toxicology. 117, 5, s. 297-305 9 s.

Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study

Bigal, M. E., Edvinsson, L., Rapoport, A. M., Lipton, R. B., Spierings, E. L. H., Diener, H-C., Burstein, R., Loupe, P. S., Ma, Y., Yang, R. & Silberstein, S. D., nov. 2015, I : Lancet neurology. 14, 11, s. 1091-100 10 s.

Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats

Johansson, S. E., Andersen, X. E., Hansen, R. H., Povlsen, G. K. & Edvinsson, L., jul. 2015, I : Acta physiologica (Oxford, England). 214, 3, s. 376-89 14 s.

A second trigeminal CGRP receptor: function and expression of the AMY1 receptor

Walker, C. S., Eftekhari, S., Bower, R. L., Wilderman, A., Insel, P. A., Edvinsson, L., Waldvogel, H. J., Jamaluddin, M. A., Russo, A. F. & Hay, D. L., jun. 2015, I : Annals of Clinical and Translational Neurology. 2, 6, s. 595-608 14 s.

CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment

Edvinsson, L., 3 mar. 2015, I : British Journal of Clinical Pharmacology.

MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats

Povlsen, G. K. & Edvinsson, L., feb. 2015, I : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 35, s. 329-337

Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion

Lukács, M., Haanes, K. A., Majláth, Z., Tajti, J., Vécsei, L., Warfvinge, K. & Edvinsson, L., 2015, I : The Journal of Headache and Pain Online. 16, s. 564

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion

Csáti, A., Edvinsson, L., Vécsei, L., Toldi, J., Fülöp, F., Tajti, J. & Warfvinge, K., 2015, I : Journal of Headache and Pain. 16, s. 99

Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier

Eftekhari, S., Salvatore, C. A., Johansson, S., Chen, T-B., Zeng, Z. & Edvinsson, L., 2015, I : Brain Research. 1600, s. 93-109

Modulation of inflammatory mediators in the trigeminal ganglion by botulinum neurotoxin type A: an organ culture study

Edvinsson, J., Warfvinge, K. & Edvinsson, L., 2015, I : Journal of Headache and Pain. 16, s. 555

Regulation of microRNAs miR-30a and miR-143 in cerebral vasculature after experimental subarachnoid hemorrhage in rats

Müller, A. H., Povlsen, G. K., Bang-Berthelsen, C. H., Kruse, L. S., Nielsen, J., Warfwinge, K. & Edvinsson, L., 2015, I : B M C Genomics. 16, s. 119

RAAS and stress markers in acute ischemic stroke: preliminary findings

Back, C., Thiesen, K. L., Olsen, K. S., Edvinsson, L., Jensen, L. T., Larsen, V. A. & Iversen, H. K., 2015, I : Acta Neurologica Scandinavica. 131, 2, s. 132-139

Treatment of acute migraine attacks

Edvinsson, L., 2015, Pharmacological Management of Headaches. Springer International Publishing, s. 53-62 10 s.

U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats

Ahnstedt, H., Mostajeran, M., Blixt, F. W., Warfwinge, K., Ansar, S., Krause, D. N. & Edvinsson, L., 10 dec. 2014, I : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Pituitary adenylate cyclase activating polypeptide and migraine

Zagami, A. S., Edvinsson, L. & Goadsby, P. J., dec. 2014, I : Annals of Clinical and Translational Neurology. 1, 12, s. 1036-40 5 s.

Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention

Ho, T. W., Connor, K. M., Zhang, Y., Pearlman, E., Koppenhaver, J., Fan, X., Lines, C., Edvinsson, L., Goadsby, P. J. & Michelson, D., 9 sep. 2014, I : Neurology. 83, 11, s. 958-66 9 s.

Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries

Haanes, K. A. & Edvinsson, L., 25 aug. 2014, I : F E B S Letters. 588, 17, s. 2936-43 8 s.

Topical non-peptide antagonists of sensory neurotransmitters substance P and CGRP do not modify patch test and prick test reactions: a vehicle-controlled, double-blind pilot study

Wallengren, J. & Edvinsson, L., jul. 2014, I : Archives of Dermatological Research. 306, 5, s. 505-9 5 s.

Heart ischaemia-reperfusion induces local up-regulation of vasoconstrictor endothelin ETB receptors in rat coronary arteries downstream of occlusion

Skovsted, G. F., Kruse, L. S., Larsen, R., Pedersen, A. F., Trautner, S., Sheykhzade, M. & Edvinsson, L., jun. 2014, I : British Journal of Pharmacology. 171, 11, s. 2726-38 13 s.

Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage

Edvinsson, L., Larsen, S. S., Maddahi, A. & Nielsen, J., jun. 2014, I : Translational Stroke Research. 5, 3, s. 365-76 12 s.

PACAP and its receptors in migraine pathophysiology

Edvinsson, L., 15 maj 2014, I : British Journal of Pharmacology.

Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage

Samraj, A. K., Müller, A. H., Grell, A-S. & Edvinsson, L., maj 2014, I : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34, 5, s. 759-63 5 s.

Differential localization and characterization of functional calcitonin gene-related peptide receptors in human subcutaneous arteries

Edvinsson, L., Ahnstedt, H., Larsen, R. & Sheykhzade, M., apr. 2014, I : Acta Physiologica (Online). 210, 4, s. 811-22 12 s.

Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients

Edvinsson, M-L., Uddman, E., Edvinsson, L. & Andersson, S., mar. 2014, I : Journal of Geriatric Cardiology. 11, 1, s. 50-6 7 s.

Apolipoprotein B of low-density lipoprotein impairs nitric oxide-mediated endothelium-dependent relaxation in rat mesenteric arteries

Zhang, Y., Zhang, W., Edvinsson, L. & Xu, C-B., 15 feb. 2014, I : European journal of pharmacology. 725, s. 10-7 8 s.

Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression

Xu, C-B., Zheng, J-P., Zhang, W., Liu, E., Edvinsson, L. & Zhang, Y., jan. 2014, I : Vascular Pharmacology. 60, 1, s. 42-8 7 s.

Potentiated adrenomedullin-induced vasorelaxation during hypoxia in organ cultured porcine coronary arteries

Hasbak, P., Sheykhzade, M., Schifter, S. & Edvinsson, L., jan. 2014, I : Journal of Cardiovascular Pharmacology. 63, 1, s. 58-67 10 s.

Walking with the IHS on basic mechanisms in headache research

Edvinsson, L., jan. 2014, I : Cephalalgia : an international journal of headache. 34, 1, s. 79

CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture

Waldsee, R., Eftekhari, S., Ahnstedt, H., Johnson, L. E. & Edvinsson, L., 2014, I : Journal of Neuroinflammation. 11, s. 90

CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function

Edvinsson, L., Povlsen, G. K., Ahnstedt, H. & Waldsee, R., 2014, I : Journal of Neuroinflammation. 11, s. 207

Comparison of the vasodilator responses of isolated human and rat middle meningeal arteries to migraine related compounds

Grände, G., Labruijere, S., Haanes, K. A., MaassenVanDenBrink, A. & Edvinsson, L., 2014, I : The Journal of Headache and Pain Online. 15, s. 22

Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulation

Johansson, S. E., Larsen, S. S., Povlsen, G. K. & Edvinsson, L., 2014, I : P L o S One. 9, 3, s. e92417

Expression and characterization of purinergic receptors in rat middle meningeal artery-potential role in migraine

Haanes, K. A. & Edvinsson, L., 2014, I : P L o S One. 9, 9, s. e108782

Refractory chronic cluster headache: a consensus statement on clinical definition from the European Headache Federation

Mitsikostas, D. D., Edvinsson, L., Jensen, R. H., Katsarava, Z., Lampl, C., Negro, A., Osipova, V., Paemeleire, K., Siva, A., Valade, D. & Martelletti, P., 2014, I : The Journal of Headache and Pain Online. 15, s. 79

Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia

Grell, A-S., Thigarajah, R., Edvinsson, L. & Samraj, A. K., 2014, I : P L o S One. 9, 12, s. e113624

Localization of CGRP receptor components, CGRP, and receptor binding sites in human and rhesus cerebellar cortex

Eftekhari, S., Salvatore, C. A., Gaspar, R. C., Roberts, R., O'Malley, S., Zeng, Z. & Edvinsson, L., dec. 2013, I : Cerebellum (London, England). 12, 6, s. 937-49 13 s.

Increased endothelin 1 type B receptors in nasal lesions of patients with granulomatosis with polyangiitis

Dimitrijevic, I. & Edvinsson, L., 28 nov. 2013, I : American Journal of Rhinology & Allergy. 27, 6, s. 444-50 7 s.

Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system

Eftekhari, S., Warfvinge, K., Blixt, F. W. & Edvinsson, L., nov. 2013, I : The journal of pain : official journal of the American Pain Society. 14, 11, s. 1289-303 15 s.

Is CGRP a marker for chronic migraine?

Silberstein, S. D. & Edvinsson, L., 1 okt. 2013, I : Neurology. 81, 14, s. 1184-5 2 s.

Role of VIP/PACAP in primary headaches

Edvinsson, L., okt. 2013, I : Cephalalgia : an international journal of headache. 33, 13, s. 1070-2 3 s.

Intracranial and extracranial arteries in migraine

MaassenVanDenBrink, A., Ibrahimi, K. & Edvinsson, L., sep. 2013, I : Lancet neurology. 12, 9, s. 847-8 2 s.

Nuclear Factor-kappaB-Mediated Endothelin Receptor Up-Regulation Increases Renal Artery Contractility in Rats

Xie, Y-H., Wang, S-W., Zhang, Y., Edvinsson, L. & Xu, C-B., 22 aug. 2013, I : Basic & clinical pharmacology & toxicology.

CGRP receptor antagonism and migraine therapy

Edvinsson, L. & Warfvinge, K., aug. 2013, I : Current Protein and Peptide Science. 14, 5, s. 386-92 7 s.

Signal transduction in cerebral arteries after subarachnoid hemorrhage-a phosphoproteomic approach

Parker, B., Larsen, M. R., Edvinsson, L. I. H. & Povlsen, G. K., aug. 2013, I : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 33, 8, s. 1259-69 11 s.

Pearls and pitfalls in neural CGRP immunohistochemistry

Warfvinge, K. & Edvinsson, L., jun. 2013, I : Cephalalgia : an international journal of headache. 33, 8, s. 593-603 11 s.

MAPK/NF-κB-dependent upregulation of kinin receptors mediates airway hyperreactivity: a new perspective for the treatment

Zhang, Y., Cardell, L-O., Edvinsson, L. & Xu, C-B., maj 2013, I : Pharmacological research : the official journal of the Italian Pharmacological Society. 71, s. 9-18 10 s.

VIP/PACAP receptors in cerebral arteries of rat: characterization, localization and relation to intracellular calcium

Erdling, A., Sheykhzade, M., Maddahi, A., Bari, F. & Edvinsson, L., apr. 2013, I : Neuropeptides (Edinburgh). 47, 2, s. 85-92 8 s.

Comparison of responses to vasoactive drugs in human and rat cerebral arteries using myography and pressurized cerebral artery method

Grände, G., Nilsson, E. & Edvinsson, L., feb. 2013, I : Cephalalgia : an international journal of headache. 33, 3, s. 152-9 8 s.

Hospital utilization and costs for spinal cord stimulation compared with enhanced external counterpulsation for refractory angina pectoris

Bondesson, S. M., Jakobsson, U., Edvinsson, L. & Hallberg, I. R., feb. 2013, I : Journal of Evaluation in Clinical Practice Online. 19, 1, s. 139-47 9 s.

Secondhand cigarette smoke exposure causes upregulation of cerebrovascular 5-HT(1) (B) receptors via the Raf/ERK/MAPK pathway in rats

Cao, L., Xu, C. B., Zhang, Y., Cao, Y. X. & Edvinsson, L., jan. 2013, I : Acta physiologica (Oxford, England). 207, 1, s. 183-93 11 s.

Altered endothelin receptor expression and affinity in spontaneously hypertensive rat cerebral and coronary arteries

Cao, L., Cao, Y-X., Xu, C-B. & Edvinsson, L., 2013, I : P L o S One. 8, 9, s. e73761

Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhage

Povlsen, G. K., Johansson, S. E., Larsen, C. C., Samraj, A. K. & Edvinsson, L., 2013, I : B M C Neuroscience. 14, s. 34 12 s.

Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries

Ahnstedt, H., Cao, L., Krause, D. N., Warfvinge, K., Säveland, H., Nilsson, L. O. & Edvinsson, L., 2013, I : P L o S One. 8, 4, s. e62698

MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries

Ansar, S., Eftekhari, S., Waldsee, R., Nilsson, E., Nilsson, O., Säveland, H. & Edvinsson, L., 2013, I : B M C Neuroscience. 14, s. 12

Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion

Rasmussen, M. N. P., Hornbak, M., Larsen, S. S., Sheykhzade, M. & Edvinsson, L., 2013, I : Journal of Vascular Research. 50, 5, s. 396-409 14 s.

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