Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria

Winther, S. A., Øllgaard, J. C., Hansen, T. W., von Scholten, B. J., Reinhard, H., Ahluwalia, T. S., Wang, Z., Gæde, P., Parving, H-H., Hazen, S., Pedersen, O. & Rossing, P., mar. 2021, I: PLoS One. 16, 3, s. e0244402 e0244402.

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Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria

Winther, S. A., Henriksen, P., Vogt, J. K., Hansen, T. H., Ahonen, L., Suvitaival, T., Hein Zobel, E., Frimodt-Møller, M., Hansen, T. W., Hansen, T., Parving, H-H., Legido-Quigley, C., Rossing, P. & Pedersen, O., dec. 2020, I: Diabetologia. 63, 12, s. 2713-2724 12 s.

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Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study

Piazza, M., Hanssen, N. M. J., Persson, F., Scheijen, J. L., van de Waarenburg, M. P. H., van Greevenbroek, M. M. J., Rossing, P., Hovind, P., Stehouwer, C. D. A., Parving, H. H. & Schalkwijk, C. G., 22 sep. 2020, I: Diabetic Medicine. s. e14405

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Profiling of gut microbiota and plasma metabolites in persons with type 1 diabetes and kidney disease

Henriksen, P., Winther, S. A., Vogt, J. K., Hansen, T. H., Ahonen, L. L., Suvitaival, T., Frimodt-Møller, M., Hansen, T. W., Hansen, T., Parving, H-H. D., Legido-Quigley, C., Rossing, P. & Pedersen, O., 25 aug. 2020, I: Diabetologia. 63, Suppl 1, s. S384 795.

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Lipoprotein(a)and renal function decline, cardiovascular disease and mortality in type 2 diabetes and microalbuminuria

Heinrich, N. S., von Scholten, B. J., Reinhard, H., Persson, F., Ahluwalia, T. S., Hansen, T. W., Parving, H-H., Jacobsen, P. K. & Rossing, P., jul. 2020, I: Journal of Diabetes and its Complications. 34, 7, s. 107593 107593.

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Association between severe diabetic retinopathy and lectin pathway proteins - an 18-year follow-up study with newly diagnosed type 1 diabetes patients

Holt, C. B., Hoffmann-Petersen, I. T., Hansen, T. K., Parving, H-H., Thiel, S., Hovind, P., Tarnow, L., Rossing, P. & Østergaard, J. A., maj 2020, I: Immunobiology. 225, 3, s. 151939 151939.

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Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials

Idzerda, N. M. A., Pena, M. J., Parving, H-H., de Zeeuw, D. & Heerspink, H. J. L., 1 okt. 2019, I: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 34, 10, s. 1699-1706

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Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study

Gæde, P., Oellgaard, J., Kruuse, C., Rossing, P., Parving, H-H. & Pedersen, O., 1 sep. 2019, I: Diabetologia. 62, 9, s. 1575-1580 6 s.

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Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes

Winther, S. A., Øllgaard, J. C., Tofte, N., Tarnow, L., Wang, Z., Ahluwalia, T. S., Jorsal, A., Theilade, S., Parving, H-H., Hansen, T. W., Hazen, S. L., Pedersen, O. & Rossing, P., aug. 2019, I: Diabetes Care. 42, 8, s. 1512-1520 9 s.

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The effect of insulin degludec on risk of symptomatic nocturnal hypoglycaemia in adults with type 1 diabetes and high risk of nocturnal severe hypoglycaemia (the HypoDeg trial): study rationale and design

Agesen, R. M., Alibegovic, A. C., Andersen, H. U., Beck-Nielsen, H., Gustenhoff, P., Hansen, T. K., Hedetoft, C., Jensen, T., Juhl, C. B., Lerche, S. S., Nørgaard, K., Parving, H-H., Tarnow, L., Thorsteinsson, B. & Pedersen-Bjergaard, U., 23 jul. 2019, I: BMC Endocrine Disorders. 19, 1, 78.

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Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

SONAR Committees and Investigators, 11 maj 2019, I: The Lancet. 393, 10184, s. 1937-1947 11 s.

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A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study

Gæde, J., Oellgaard, J., Ibsen, R., Gæde, P., Nørtoft, E., Parving, H-H., Kjellberg, J. & Pedersen, O., 1 jan. 2019, I: Diabetologia. 62, 1, s. 147-155 9 s.

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Application of urinary proteomics as possible risk predictor of renal and cardiovascular complications in patients with type 2-diabetes and microalbuminuria

Oellgaard, J., Gæde, P., Persson, F., Rossing, P., Parving, H-H. & Pedersen, O., 1 dec. 2018, I: Journal of Diabetes and its Complications. 32, 12, s. 1133-1140 8 s.

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NT-proBNP predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk

Idzerda, N. M. A., Persson, F., Pena, M. J., Brenner, B. M., Brunel, P., Chaturvedi, N., McMurray, J. J., Parving, H-H., de Zeeuw, D. & Heerspink, H. J. L., dec. 2018, I: Diabetes, Obesity and Metabolism Online. 20, 12, s. 2899-2904 5 s.

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Urinary tubular biomarkers as predictors of kidney function decline, cardiovascular events and mortality in microalbuminuric type 2 diabetic patients

Rotbain Curovic, V., Hansen, T. W., Eickhoff, M. K., von Scholten, B. J., Reinhard, H., Jacobsen, P. K., Persson, F., Parving, H-H. & Rossing, P., nov. 2018, I: Acta Diabetologica. 55, 11, s. 1143-1150 7 s.

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Collagen Type III Degradation Is Associated with Deterioration of Kidney Function in Patients with Type 2 Diabetes with Microalbuminuria

Genovesa, F., Hansen, T. W., Rasmussen, D. G. K., Nielsen, S. H., Reinhard, H., Von Scholten, B. J., Persson, F., Jacobsen, P. K., Parving, H-H. D., Karsdal, M. A. & Rossing, P., okt. 2018, I: Diabetologia. 61, s. S492-S492 1 s., 1001.

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Determining the optimal dose of atrasentan by evaluating the exposure-response relationships of albuminuria and bodyweight

Koomen, J. V., Stevens, J., Mostafa, N. M., Parving, H-H., de Zeeuw, D. & Heerspink, H. J. L., aug. 2018, I: Diabetes, Obesity and Metabolism. 20, 8, s. 2019-2022 4 s.

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Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study

Oellgaard, J., Gæde, P., Rossing, P., Rørth, R., Køber, L., Parving, H-H. & Pedersen, O., aug. 2018, I: Diabetologia. 61, 8, s. 1724-1733 9 s.

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Higher Collagen VI Formation Is Associated With All-Cause Mortality in Patients With Type 2 Diabetes and Microalbuminuria

Rasmussen, D. G. K., Hansen, T. W., von Scholten, B. J., Nielsen, S. H., Reinhard, H., Parving, H-H., Tepel, M., Karsdal, M. A., Jacobsen, P. K., Genovese, F. & Rossing, P., jul. 2018, I: Diabetes Care. 41, 7, s. 1493-1500 7 s.

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Rationale and protocol of the Study Of diabetic Nephropathy with AtRasentan (SONAR) trial: A clinical trial design novel to diabetic nephropathy

Heerspink, H. J. L., Andress, D. L., Bakris, G., Brennan, J. J., Correa-Rotter, R., Dey, J., Hou, F. F., Kitzman, D. W., Kohan, D., Makino, H., McMurray, J., Perkovic, V., Tobe, S., Wigderson, M., Parving, H-H. & de Zeeuw, D., jun. 2018, I: Diabetes, Obesity and Metabolism. 20, 6, s. 1369-1376 8 s.

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COLLAGEN TYPE III DEGRADATION IS ASSOCIATED WITH DETERIORATION OF KIDNEY FUNCTION IN PATIENTS WITH TYPE 2 DIABETES WITH MICROALBUMINURIA.

Frimodt-Moller, M., Genovese, F., Hansen, T., Rasmussen, D., Nielsen, S., Reinhard, H., von Scholten, B. J., Persson, F., Jacobsen, P., Parving, H-H., Karsdal, M. & Rossing, P., 1 maj 2018, I: Nephrology Dialysis Transplantation. 33, 1, 1 s., SP418.

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Effect of Insulin Analogs on Frequency of Non-Severe Hypoglycemia in Patients with Type 1 Diabetes Prone to Severe Hypoglycemia: Much Higher Rates Detected by Continuous Glucose Monitoring than by Self-Monitoring of Blood Glucose-The HypoAna Trial

Agesen, R. M., Kristensen, P. L., Beck-Nielsen, H., Nørgaard, K., Perrild, H., Jensen, T., Parving, H-H., Thorsteinsson, B., Tarnow, L. & Pedersen-Bjergaard, U., 1 mar. 2018, I: Diabetes Technology and Therapeutics. 20, 3, s. 247-256.

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Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: analysis of ALTITUDE trial

Seferovic, J. P., Pfeffer, M. A., Claggett, B., Desai, A. S., de Zeeuw, D., Haffner, S. M., McMurray, J. J. V., Parving, H-H., Solomon, S. D. & Chaturvedi, N., mar. 2018, I: Diabetologia. 61, 3, s. 581-588 7 s.

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Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort

Ferreira, I., Hovind, P., Schalkwijk, C. G., Parving, H-H., Stehouwer, C. D. A. & Rossing, P., jan. 2018, I: Diabetologia. 61, 1, s. 231-241 10 s.

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Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes - An observational follow-up study

Frimodt-Møller, M., von Scholten, B. J., Reinhard, H., Jacobsen, P. K., Hansen, T. W., Persson, F. I., Parving, H-H. & Rossing, P., 2018, I: P L o S One. 13, 4, s. e0196634

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Fasting Plasma Trimethylamine-N-Oxide as a Risk Marker of Poor Renal Outcomes, Cardiovascular Disease, and Mortality in Patients with Type 1 Diabetes with Diabetic Nephropathy

Winther, S. A., Øllgaard, J. C., Parving, H-H. D., Hazen, S. L., Pedersen, O. & Rossing, P., 4 nov. 2017, I: Journal of the American Society of Nephrology. 28, s. 102-103 SA-OR113.

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Plasma high-sensitivity troponin T predicts end-stage renal disease and cardiovascular and all-cause mortality in patients with type 1 diabetes and diabetic nephropathy

Galsgaard, J., Persson, F., Hansen, T. W., Jorsal, A., Tarnow, L., Parving, H-H. & Rossing, P., nov. 2017, I: Kidney International. 92, 5, s. 1242-1248 6 s.

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Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study

Lindhardt, M., Persson, F. I., Zürbig, P., Stalmach, A., Mischak, H., de Zeeuw, D., Lambers Heerspink, H., Klein, R., Orchard, T., Porta, M., Fuller, J., Bilous, R., Chaturvedi, N., Parving, H-H. & Rossing, P., nov. 2017, I: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 32, 11, s. 1866-1873 7 s.

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ESRD After Heart Failure, Myocardial Infarction, or Stroke in Type 2 Diabetic Patients With CKD

Charytan, D. M., Solomon, S. D., Ivanovich, P., Remuzzi, G., Cooper, M. E., McGill, J. B., Parving, H-H., Parfrey, P., Singh, A. K., Burdmann, E. A., Levey, A. S., de Zeeuw, D., Eckardt, K-U., McMurray, J. J. V., Claggett, B., Lewis, E. F. & Pfeffer, M. A., okt. 2017, I: American journal of kidney diseases : the official journal of the National Kidney Foundation. 70, 4, s. 522-531 10 s.

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Toe-brachial index as a predictor of cardiovascular disease and all-cause mortality in people with type 2 diabetes and microalbuminuria

Zobel, E. H., von Scholten, B. J., Reinhard, H., Persson, F., Hansen, T. W., Parving, H. H., Jacobsen, P. K. & Rossing, P., okt. 2017, I: Diabetologia. 60, 10, s. 1883-1891 8 s.

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Symmetric and asymmetric dimethylarginine as risk markers of cardiovascular disease, all-cause mortality and deterioration in kidney function in persons with type 2 diabetes and microalbuminuria

Zobel, E. H., von Scholten, B. J., Reinhard, H., Persson, F., Teerlink, T., Hansen, T. W., Parving, H-H., Jacobsen, P. K. & Rossing, P., 11 jul. 2017, I: Cardiovascular Diabetology. 16, 1, s. e88

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Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes

Ostergaard, J. A., Thiel, S., Hoffmann-Petersen, I. T., Hovind, P., Parving, H-H., Tarnow, L., Rossing, P. & Hansen, T. K., apr. 2017, I: Diabetes - Metabolism: Research and Reviews (Online). 33, 5, s. e2895

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Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits

Oellgaard, J., Gaede, P., Rossing, P., Persson, F., Parving, H-H. & Pedersen, O., apr. 2017, I: Kidney International. 91, 4, s. 982-988 7 s.

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Longitudinal Estimated GFR Trajectories in Patients With and Without Type 2 Diabetes and Nephropathy

Weldegiorgis, M., de Zeeuw, D., Li, L., Parving, H-H., Hou, F. F., Remuzzi, G., Greene, T. & Heerspink, H. J. L., jan. 2017, I: American journal of kidney diseases : the official journal of the National Kidney Foundation. 71, 1, s. 91-101 11 s.

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Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Jorsal, A., Parving, H-H., Tarnow, L., Theilade, S., Rossing, P., Schalkwijk, C. G. & Stehouwer, C. D. A., 2017, I: Cardiovascular Diabetology. 16, 1, s. e139

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Comparing effects of insulin analogues and human insulin on nocturnal glycaemia in hypoglycaemia-prone people with Type 1 diabetes

Kristensen, P. L., Tarnow, L., Bay, C., Nørgaard, K., Jensen, T., Parving, H-H., Perrild, H., Beck-Nielsen, H., Christiansen, J. S., Thorsteinsson, B. & Pedersen-Bjergaard, U., 2017, I: Diabetic Medicine. 34, 5, s. 625-631

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Comparison of exposure response relationship of atrasentan between North American and Asian populations

Heerspink, H. J. L., Makino, H., Andress, D., Brennan, J. J., Correa-Rotter, R., Coll, B., Davis, J. W., Idler, K., Kohan, D. E., Liu, M., Perkovic, V., Remuzzi, G., Tobe, S. W., Toto, R., Parving, H-H. & de Zeeuw, D., 2017, I: Diabetes, Obesity and Metabolism. 19, 4, s. 545-552

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Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate

Christensen, R. H., von Scholten, B. J., Hansen, C. S., Heywood, S. E., Rosenmeier, J. B., Andersen, U. B., Hovind, P., Reinhard, H., Parving, H-H., Pedersen, B. K., Jørgensen, M. E., Jacobsen, P. K. & Rossing, P., 2017, I: European journal of preventive cardiology. 24, 14, s. 1517-1524

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Higher Plasma Methylglyoxal Levels are Associated with Incident Cardiovascular Disease in Individuals with Type 1 Diabetes: a 12-Year Follow-Up Study

Hanssen, N. M. J., Scheijen, J. L. J. M., Jorsal, A., Parving, H-H., Tarnow, L., Rossing, P., Stehouwer, C. D. A. & Schalkwijk, C. G., 2017, I: Diabetes. 66, 8, s. 2278-83

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