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Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7

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@article{feb3f09abc8f4b6288d07772da903682,
title = "Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7",
abstract = "BACKGROUND: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components.METHODS: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures.RESULTS: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p < .001; d = 0.75) as did children at FHR-BP (p < .05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p = .01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p < .05).LIMITATIONS: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report.CONCLUSIONS: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.",
author = "Nicoline Hemager and Signe Vangkilde and Anne Thorup and Camilla Christiani and Ditte Ellersgaard and Spang, {Katrine S{\o}borg} and Burton, {Birgitte Klee} and Greve, {Aja Neergaard} and Gantriis, {Ditte Lou} and Ole Mors and Jepsen, {Jens Richardt M{\o}llegaard} and Merete Nordentoft and Plessen, {Kerstin Jessica}",
note = "Copyright {\textcopyright} 2019. Published by Elsevier B.V.",
year = "2019",
month = nov,
day = "1",
doi = "10.1016/j.jad.2019.07.079",
language = "English",
volume = "258",
pages = "56--65",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder

T2 - The Danish high risk and resilience study VIA 7

AU - Hemager, Nicoline

AU - Vangkilde, Signe

AU - Thorup, Anne

AU - Christiani, Camilla

AU - Ellersgaard, Ditte

AU - Spang, Katrine Søborg

AU - Burton, Birgitte Klee

AU - Greve, Aja Neergaard

AU - Gantriis, Ditte Lou

AU - Mors, Ole

AU - Jepsen, Jens Richardt Møllegaard

AU - Nordentoft, Merete

AU - Plessen, Kerstin Jessica

N1 - Copyright © 2019. Published by Elsevier B.V.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - BACKGROUND: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components.METHODS: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures.RESULTS: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p < .001; d = 0.75) as did children at FHR-BP (p < .05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p = .01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p < .05).LIMITATIONS: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report.CONCLUSIONS: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.

AB - BACKGROUND: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components.METHODS: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures.RESULTS: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p < .001; d = 0.75) as did children at FHR-BP (p < .05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p = .01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p < .05).LIMITATIONS: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report.CONCLUSIONS: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.

UR - http://www.scopus.com/inward/record.url?scp=85070095442&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2019.07.079

DO - 10.1016/j.jad.2019.07.079

M3 - Journal article

C2 - 31394459

VL - 258

SP - 56

EP - 65

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 57782210