Forskning
Udskriv Udskriv
Switch language
Region Hovedstadens Psykiatri - en del af Københavns Universitetshospital
E-pub ahead of print

Evaluating the interrelations between the autism polygenic score and psychiatric family history in risk for autism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Vagotomy and the risk of mental disorders: A nationwide population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Bereavement Among Adult Siblings: An Examination of Health Services Utilization and Mental Health Outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Diana Schendel
  • Thomas Munk Laursen
  • Clara Albiñana
  • Bjarni Vilhjalmsson
  • Christine Ladd-Acosta
  • Margaret Danielle Fallin
  • Kelly Benke
  • Brian Lee
  • Jakob Grove
  • Amy Kalkbrenner
  • Linda Ejlskov
  • David Hougaard
  • Jonas Bybjerg-Grauholm
  • Marie Baekvad-Hansen
  • Anders D Børglum
  • Thomas Werge
  • Merete Nordentoft
  • Preben Bo Mortensen
  • Esben Agerbo
Vis graf over relationer

Psychiatric family history or a high autism polygenic risk score (PRS) have been separately linked to autism spectrum disorder (ASD) risk. The study aimed to simultaneously consider psychiatric family history and individual autism genetic liability (PRS) in autism risk. We performed a case-control study of all Denmark singleton births, May 1981-December 2005, in Denmark at their first birthday and a known mother. Cases were diagnosed with ASD before 2013 and controls comprised a random sample of 30,000 births without ASD, excluding persons with non-Denmark-born parents, missing ASD PRS, non-European ancestry. Adjusted odds ratios (aOR) were estimated for ASD by PRS decile and by psychiatric history in parents or full siblings (8 mutually-exclusive categories) using logistic regression. Adjusted ASD PRS z-score least-squares means were estimated by psychiatric family history category. ASD risk (11,339 ASD cases; 20,175 controls) from ASD PRS was not substantially altered after accounting for psychiatric family history (e.g., ASD PRS 10th decile aOR: 2.35 (95% CI 2.11-2.63) before vs 2.11 (95% CI 1.91-2.40) after adjustment) nor from psychiatric family history after accounting for ASD PRS (e.g., ASD family history aOR: 6.73 (95% CI 5.89-7.68) before vs 6.32 (95% CI 5.53-7.22) after adjustment). ASD risk from ASD PRS varied slightly by psychiatric family history. While ASD risk from psychiatric family history was not accounted for by ASD PRS and vice versa, risk overlap between the two factors will likely increase as measures of genetic risk improve. The two factors are best viewed as complementary measures of family-based autism risk. LAY SUMMARY: Autism risk from a history of mental disorders in the immediate family was not explained by a measure of individual genetic risk (autism polygenic risk score) and vice versa. That is, genetic risk did not appear to overlap family history risk. As genetic measures for autism improve then the overlap in autism risk from family history versus genetic factors will likely increase, but further study may be needed to fully determine the components of risk and how they are inter-related between these key family factors. Meanwhile, the two factors may be best viewed as complementary measures of autism family-based risk.

OriginalsprogEngelsk
TidsskriftAutism research : official journal of the International Society for Autism Research
ISSN1939-3806
DOI
StatusE-pub ahead of print - 19 okt. 2021

Bibliografisk note

© 2021 International Society for Autism Research and Wiley Periodicals LLC.

ID: 69273644