Udskriv Udskriv
Switch language
Region Hovedstadens Psykiatri - en del af Københavns Universitetshospital

Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. No evidence of associations between genetic liability for schizophrenia and development of cannabis use disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Tamsyn E Van Rheenen
  • Vanessa Cropley
  • Birgitte Fagerlund
  • Cassandra Wannan
  • Jason Bruggemann
  • Rhoshel K Lenroot
  • Suresh Sundram
  • Cynthia Shannon Weickert
  • Thomas W Weickert
  • Andrew Zalesky
  • Chad A Bousman
  • Christos Pantelis
Vis graf over relationer

BACKGROUND: In schizophrenia, relative stability in the magnitude of cognitive deficits across age and illness duration is inconsistent with the evidence of accelerated deterioration in brain regions known to support these functions. These discrepant brain-cognition outcomes may be explained by variability in cognitive reserve (CR), which in neurological disorders has been shown to buffer against brain pathology and minimize its impact on cognitive or clinical indicators of illness.

METHODS: Age-related change in fluid reasoning, working memory and frontal brain volume, area and thickness were mapped using regression analysis in 214 individuals with schizophrenia or schizoaffective disorder and 168 healthy controls. In patients, these changes were modelled as a function of CR.

RESULTS: Patients showed exaggerated age-related decline in brain structure, but not fluid reasoning compared to controls. In the patient group, no moderation of age-related brain structural change by CR was evident. However, age-related cognitive change was moderated by CR, such that only patients with low CR showed evidence of exaggerated fluid reasoning decline that paralleled the exaggerated age-related deterioration of underpinning brain structures seen in all patients.

CONCLUSIONS: In schizophrenia-spectrum illness, CR may negate ageing effects on fluid reasoning by buffering against pathologically exaggerated structural brain deterioration through some form of compensation. CR may represent an important modifier that could explain inconsistencies in brain structure - cognition outcomes in the extant literature.

TidsskriftPsychological Medicine
Udgave nummer9
Sider (fra-til)1475-1489
Antal sider15
StatusUdgivet - jul. 2020

ID: 58217487