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Hvidovre Hospital - a part of Copenhagen University Hospital

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Research output: Contribution to journalJournal articlepeer-review

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  • Hyungjun Yang
  • Hengameh Chloé Mirsepasi-Lauridsen
  • Carsten Struve
  • Joannie M Allaire
  • Adeline Sivignon
  • Wayne Vogl
  • Else S Bosman
  • Caixia Ma
  • Abbas Fotovati
  • Gregor S Reid
  • Xiaoxia Li
  • Andreas Munk Petersen
  • Sébastien G Gouin
  • Nicolas Barnich
  • Kevan Jacobson
  • Hong Bing Yu
  • Karen Angeliki Krogfelt
  • Bruce A Vallance
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Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli. These "pathobionts" exhibit pathogenic properties, but their potential to promote UC is unclear due to the lack of relevant animal models. Here, we established a mouse model using a representative UC pathobiont strain (p19A), and mice lacking single immunoglobulin and toll-interleukin 1 receptor domain (SIGIRR), a deficiency increasing susceptibility to gut infections. Strain p19A was found to adhere to the cecal mucosa of Sigirr -/- mice, causing modest inflammation. Moreover, it dramatically worsened dextran sodium sulfate-induced colitis. This potentiation was attenuated using a p19A strain lacking α-hemolysin genes, or when we targeted pathobiont adherence using a p19A strain lacking the adhesin FimH, or following treatment with FimH antagonists. Thus, UC pathobionts adhere to the intestinal mucosa, and worsen the course of colitis in susceptible hosts.

Original languageEnglish
JournalGut Microbes
Issue number1
Pages (from-to)1847976
Number of pages19
Publication statusPublished - 1 Dec 2020

    Research areas

  • Crohn&#8217, Inflammatory bowel disease, Ulcerative Colitis, in vivo mouse model, intestinal microbiota, s disease

ID: 61405328