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Hvidovre Hospital - a part of Copenhagen University Hospital
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Time-dependent and anisotropic diffusion in the heart: linear and spherical tensor encoding with varying degree of motion compensation

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Spherical tensor encoding (STE) can potentially shorten acquisition of mean diffusivity (MD) compared to the traditional linear tensor encoding (LTE). To avoid negative effects of motion, e.g. in the heart, motion compensation is needed. However, motion compensation requires altering diffusion gradient waveforms and their sensitivities to time-dependent diffusion. To exclude motion, we first investigated LTE and STE with different degrees of motion compensation in ex vivo pig hearts. We observed significantly different MD, which can be attributed to time-dependent diffusion and microscopic diffusion anisotropy. Our analysis suggests that time-dependent diffusion is a critical determinant of MD in the myocardium.

Original languageEnglish
Title of host publicationProceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages3
PublisherThe International Society for Magnetic Resonance in Medicine
Publication date2020
Pages1-3
Article number4300
Publication statusPublished - 2020

ID: 62034806