Print page Print page
Switch language
Hvidovre Hospital - a part of Copenhagen University Hospital

The impact of physical training on length of hospital stay and physical function in patients hospitalized with community-acquired pneumonia: protocol for a randomized controlled trial

Research output: Contribution to journalJournal articlepeer-review

  • Camilla Koch Ryrsø
  • Daniel Faurholt-Jepsen
  • Christian Ritz
  • Bente Klarlund Pedersen
  • Maria Hein Hegelund
  • Arnold Matovu Dungu
  • Adin Sejdic
  • Birgitte Lindegaard
  • Rikke Krogh-Madsen
View graph of relations

BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual care for CAP on length of hospital stay, risk of readmission, mortality risk, physical capacity, muscle and fat mass, muscle strength, metabolic function, systemic inflammation, health-related quality of life, and physical activity level.

METHODS: This study is a randomized controlled trial with three parallel experimental arms. Based on a sample size calculation, a total of 210 patients admitted with CAP at Nordsjællands Hospital, Hillerød, Denmark, will be recruited. Patients will be randomly allocated (1:1:1) to either (1) standard usual care, (2) standard usual care combined with in-bed cycling, or (3) standard usual care combined with exercises from a booklet. The primary outcome is differences in length of hospital stay between groups, with secondary outcomes being differences between groups in time to (1) 90-day readmission and (2) 180-day mortality. Further secondary outcomes are differences in changes from baseline between groups in (3) lean mass, (4) fat mass, (5) fat-free mass, (6) physical capacity, (7) health-related quality of life, (8) systemic inflammation, and (9) physical activity level after discharge. Data on length of hospital stay, readmission, and mortality will be collected from patient files, while total lean, fat, and fat-free mass will be quantitated by dual-energy x-ray absorptiometry and bioelectrical impedance analysis. Physical function will be assessed using grip strength, 30-s chair stand tests, and Barthel Index-100. Health-related quality of life will be assessed with the EQ-5D-5L questionnaire. Systemic inflammation will be assessed in blood samples, while accelerometers are used for measuring physical activity.

DISCUSSION: If a simple physical training program appears to diminish the impact of critical illness and hospitalization on clinical outcome, mobility, and health-related quality of life, it may lead to novel therapeutic approaches in the treatment of patients hospitalized with CAP.

TRIAL REGISTRATION: NCT04094636 . Registered on 1 April 2019.

Original languageEnglish
Article number571
Issue number1
Pages (from-to)571
Publication statusPublished - 28 Aug 2021

    Research areas

  • Community-Acquired Infections/diagnosis, Exercise, Humans, Length of Stay, Pneumonia/diagnosis, Quality of Life, Randomized Controlled Trials as Topic, Lean mass, Physical training, Length of hospital stay, Community-acquired pneumonia, Functional ability

ID: 67445718