Research
Print page Print page
Switch language
Hvidovre Hospital - a part of Copenhagen University Hospital
Published

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns

Research output: Contribution to journalJournal articleResearchpeer-review

  1. High-risk and low-risk human papillomavirus and the absolute risk of cervical intraepithelial neoplasia or cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effect of smoking cessation on gestational and postpartum weight gain and neonatal birth weight

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Awareness of endometrial cancer risk and compliance with screening in hereditary nonpolyposis colorectal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cytokines and the Risk of Preterm Delivery in Twin Pregnancies

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Chance of live birth: a nationwide, registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Identification of a unique epigenetic profile in women with diminished ovarian reserve

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and their newborns and the association of such antibodies with obstetric and neonatal outcomes.

METHODS: From April 4 to July 3, 2020, in a single university hospital in Denmark, all parturient women and their partners were invited to participate in the study, along with their newborns. Participating women and partners had a pharyngeal swab and a blood sample taken at admission; immediately after delivery, a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by polymerase chain reaction, and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history and obstetric and neonatal information were available.

RESULTS: A total of 1,313 parturient women (72.5.% of all women admitted for delivery at the hospital in the study period), 1,188 partners, and 1,206 newborns participated in the study. The adjusted serologic prevalence was 2.6% in women and 3.5% in partners. Seventeen newborns had SARS-CoV-2 immunoglobulin G (IgG) antibodies, and none had immunoglobulin M antibodies. No associations between SARS-CoV-2 antibodies and obstetric or neonatal complications were found (eg, preterm birth, preeclampsia, cesarean delivery, Apgar score, low birth weight, umbilical arterial pH, need for continuous positive airway pressure, or neonatal admission), but statistical power to detect such differences was low. Full serologic data from 1,051 families showed an absolute risk of maternal infection of 39% if the partner had antibodies.

CONCLUSION: We found no association between SARS-CoV-2 infection and obstetric or neonatal complications. Sixty-seven percent of newborns delivered by mothers with antibodies had SARS-CoV-2 IgG antibodies. A limitation of our study is that we lacked statistical power to detect small but potentially meaningful differences between those with and without evidence of infection.

Original languageEnglish
JournalObstetrics and Gynecology
Volume137
Issue number1
Pages (from-to)49-55
Number of pages7
ISSN0029-7844
DOIs
Publication statusPublished - 1 Jan 2021

Bibliographical note

Copyright © 2020 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.

    Research areas

  • Adult, Antibodies, Viral/blood, COVID-19 Testing/statistics & numerical data, COVID-19/blood, Denmark/epidemiology, Female, Hospitalization, Hospitals, University, Humans, Immunoglobulin G/blood, Immunoglobulin M/blood, Infant, Newborn/blood, Infectious Disease Transmission, Vertical/statistics & numerical data, Male, Obstetric Labor Complications/epidemiology, Pregnancy, Pregnancy Complications, Infectious/epidemiology, Pregnancy Outcome/epidemiology, Premature Birth/epidemiology, Regression Analysis, Risk Factors, SARS-CoV-2/immunology, Sexual Partners

ID: 61406066