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Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T

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Ageing has been associated with widespread neurochemical changes and cognitive decline. The increased sensitivity and resolution of 1H-MRS at 7T could shed new light on the potential relationship between neurochemistry and cognition during ageing. Our data show that primarily levels of glial metabolic markers, and not neuronal markers, differed between younger, middle-aged and older normal individuals and were correlated with visuo-spatial working memory performance across these age groups. This suggests that glial markers may be more affected by ageing than neuronal markers and that there is a potential association between glial markers and visuo-spatial working memory performance during ageing.
Original languageEnglish
Title of host publicationProceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages1
PublisherThe International Society for Magnetic Resonance in Medicine
Publication date2020
Article number1854
Publication statusPublished - 2020

ID: 62050476