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Hvidovre Hospital - a part of Copenhagen University Hospital
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Lung ultrasound findings following COVID-19 hospitalization: A prospective longitudinal cohort study

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  • Caroline Espersen
  • Elke Platz
  • Alia Saed Alhakak
  • Morten Sengeløv
  • Jakob Øystein Simonsen
  • Niklas Dyrby Johansen
  • Filip Søskov Davidovski
  • Jacob Christensen
  • Henning Bundgaard
  • Christian Hassager
  • Reza Jabbari
  • Jørn Carlsen
  • Ole Kirk
  • Matias Greve Lindholm
  • Ole Peter Kristiansen
  • Olav Wendelboe Nielsen
  • Klaus Nielsen Jeschke
  • Charlotte Suppli Ulrik
  • Pradeesh Sivapalan
  • Kasper Iversen
  • Jens Ulrik Stæhr Jensen
  • Morten Schou
  • Søren Helbo Skaarup
  • Mats Christian Højbjerg Lassen
  • Kristoffer Grundtvig Skaarup
  • Tor Biering-Sørensen
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BACKGROUND: Lung ultrasound (LUS) is a useful tool for diagnosis and monitoring in patients with active COVID-19-infection. However, less is known about the changes in LUS findings after a hospitalization for COVID-19.

METHODS: In a prospective, longitudinal study in patients with COVID-19 enrolled from non-ICU hospital units, adult patients underwent 8-zone LUS and blood sampling both during the hospitalization and 2-3 months after discharge. LUS images were analyzed blinded to clinical variables and outcomes.

RESULTS: A total of 71 patients with interpretable LUS at baseline and follow up (mean age 64 years, 61% male, 24% with acute respiratory distress syndrome (ARDS)) were included. The follow-up LUS was performed a median of 72 days after the initial LUS performed during hospitalization. At baseline, 87% had pathologic LUS findings in ≥1 zone (e.g. ≥3 B-lines, confluent B-lines or subpleural or lobar consolidation), whereas 30% had pathologic findings at follow-up (p < 0.001). The total number of B-lines and LUS score decreased significantly from hospitalization to follow-up (median 17 vs. 4, p < 0.001 and 4 vs. 0, p < 0.001, respectively). On the follow-up LUS, 28% of all patients had ≥3 B-lines in ≥1 zone, whereas in those with ARDS during the baseline hospitalization (n = 17), 47% had ≥3 B-lines in ≥1 zone.

CONCLUSION: LUS findings improved significantly from hospitalization to follow-up 2-3 months after discharge in COVID-19 survivors. However, persistent B-lines were frequent at follow-up, especially among those who initially had ARDS. LUS seems to be a promising method to monitor COVID-19 lung changes over time.

CLINICALTRIALS:

GOV ID: NCT04377035.

Original languageEnglish
Article number106826
JournalRespiratory medicine
Volume197
Pages (from-to)1-8
Number of pages8
ISSN0954-6111
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

    Research areas

  • COVID-19, Longitudinal follow-up, Lung ultrasound

ID: 77581532