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Hvidovre Hospital - a part of Copenhagen University Hospital
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In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark

Research output: Contribution to journalJournal articlepeer-review

DOI

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  • Rasmus K Hare
  • Jan B Gertsen
  • Karen M T Astvad
  • Kristine B Degn
  • Anders Løkke
  • Marc Stegger
  • Paal S Andersen
  • Lise Kristensen
  • Maiken C Arendrup
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We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

Original languageEnglish
JournalEmerging Infectious Diseases (Print Edition)
Volume25
Issue number3
Pages (from-to)577-580
Number of pages4
ISSN1080-6040
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • Aspergillosis/diagnosis, Aspergillus fumigatus/drug effects, Azoles/pharmacology, Cytochrome P-450 Enzyme System/genetics, Denmark/epidemiology, Drug Resistance, Fungal, Fungal Proteins/genetics, Humans, Male, Middle Aged, Mutation, Phylogeny, Promoter Regions, Genetic, Selection, Genetic, Tandem Repeat Sequences, Tomography, X-Ray Computed

ID: 59157876