Research
Print page Print page
Switch language
Hvidovre Hospital - a part of Copenhagen University Hospital
Published

Human Papillomavirus Testing in the Last Cervical Screening Round at Age 60-64 Years

Research output: Contribution to journalJournal articlepeer-review

  1. High-risk and low-risk human papillomavirus and the absolute risk of cervical intraepithelial neoplasia or cancer

    Research output: Contribution to journalJournal articlepeer-review

  2. Subcuticular suture compared with staples for skin closure after cesarean delivery: A randomized controlled trial

    Research output: Contribution to journalJournal articlepeer-review

  3. Effect of smoking cessation on gestational and postpartum weight gain and neonatal birth weight

    Research output: Contribution to journalJournal articlepeer-review

  4. Awareness of endometrial cancer risk and compliance with screening in hereditary nonpolyposis colorectal cancer

    Research output: Contribution to journalJournal articlepeer-review

  1. Breech and induction. Time for evidence-based informed consent

    Research output: Contribution to journalLetterpeer-review

  2. Histological outcomes in HPV-screened elderly women in Denmark

    Research output: Contribution to journalJournal articlepeer-review

  3. Human papilloma virus vaccination and its real-life efficacy

    Research output: Contribution to journalEditorialpeer-review

View graph of relations

OBJECTIVE: To compare the real-life screening outcomes after cytology was replaced by human papillomavirus (HPV) testing for women aged 60-64 years.

METHODS: Using the Danish national pathology register, we compared screening outcomes during two consecutive calendar periods, one where women were screened with cytology and one where most women were screened with HPV testing. Our primary outcomes were the proportions of women with positive test results, high-grade cervical intraepithelial neoplasia (CIN 2 or worse), and cervical cancer.

RESULTS: Women screened during the HPV testing period were more likely to have a positive screening test result than were women screened during the cytology period (relative proportion 2.80, 95% CI 2.65-2.96). The detection of CIN 2 or worse was also increased (relative proportion 1.54, 95% CI 1.31-1.80), whereas there was no increase in screen-detected cervical cancer diagnoses (relative proportion 1.27, 95% CI 0.76-2.12). Within the first 4 years after a negative screening test result, including 168,477 woman-years at risk after a negative screen result in the HPV period and 451,421 woman-years after a negative screen result in the cytology period, the risk of a cervical cancer diagnosis was approximately 4 per 100,000 woman-years and was similar for both screening tests (relative risk 0.99, 95% CI 0.41-2.35).

CONCLUSION: Human papillomavirus testing led to more positive screening test results and diagnoses of high-grade CIN lesions. Few women were diagnosed with cervical cancer after a negative screening test result.

Original languageEnglish
JournalObstetrics and Gynecology
Volume138
Issue number3
Pages (from-to)389-397
Number of pages9
ISSN0029-7844
DOIs
Publication statusPublished - 1 Sep 2021

    Research areas

  • Cervical Intraepithelial Neoplasia/epidemiology, Denmark/epidemiology, Female, Humans, Incidence, Middle Aged, Papillomaviridae/isolation & purification, Papillomavirus Infections/epidemiology, Registries, Uterine Cervical Neoplasms/epidemiology, Vaginal Smears

ID: 66981983