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Demographic, lifestyle and comorbid risk factors for all-cause mortality in a Danish cohort of middle-aged adults with incident asthma

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@article{97dd7ca2bc7b4622bcc40e053e0739e2,
title = "Demographic, lifestyle and comorbid risk factors for all-cause mortality in a Danish cohort of middle-aged adults with incident asthma",
abstract = "OBJECTIVE: We aimed to identify factors associated with all-cause mortality in adults with incident asthma.DESIGN AND SETTING: Cross-sectional cohort study, in the metropolitan areas of Copenhagen and Aarhus, Denmark.PARTICIPANTS: Adults aged 50-64 years enrolled in the Danish Diet, Cancer, and Health cohort were followed up from baseline (1993-1997) in the National Patients Registry for first-time admissions for asthma and vital status. We defined incident asthma as at least one first-time hospital admission with asthma as the primary registered diagnosis between baseline and end of follow-up (2013) in participants without previously known asthma. Among the cohort comprising 57 053 individuals, we identified 785 adults (aged 50-64) with incident asthma, of whom 76 died during follow-up.PRIMARY AND SECONDARY OUTCOME MEASURES: Baseline reported socioeconomic and lifestyle traits, and comorbidities associated with all-cause mortality.RESULTS: Self-reported leisure-time physical activity was associated with a substantial reduction in risk with an HR of 0.53 (95% CI 0.33 to 0.85). Being male, single and having a diagnosis of hypertension or diabetes were associated with an increased risk of all-cause mortality with an HR of 1.83 (95% CI 1.14 to 2.38), 2.16 (95% CI 2.06 to 4.40), 2.47 (95% CI 1.54 to 3.95) and of 2.42 (95% CI 0.96 to 6.11), respectively.CONCLUSIONS: This long-term study of adults with hospital contacts for incident asthma revealed that self-reported leisure-time physical activity is associated with an approximately 50% reduction in all-cause mortality. In contrast, both hypertension and diabetes were associated with a higher risk of mortality.",
keywords = "adult thoracic medicine, asthma, epidemiology",
author = "Tupper, {Oliver Djurhuus} and Andersen, {Zorana Jovanovic} and Ulrik, {Charlotte Suppli}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = oct,
day = "4",
doi = "10.1136/bmjopen-2021-049243",
language = "English",
volume = "11",
pages = "1--7",
journal = "BMJ Paediatrics Open ",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Demographic, lifestyle and comorbid risk factors for all-cause mortality in a Danish cohort of middle-aged adults with incident asthma

AU - Tupper, Oliver Djurhuus

AU - Andersen, Zorana Jovanovic

AU - Ulrik, Charlotte Suppli

N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/10/4

Y1 - 2021/10/4

N2 - OBJECTIVE: We aimed to identify factors associated with all-cause mortality in adults with incident asthma.DESIGN AND SETTING: Cross-sectional cohort study, in the metropolitan areas of Copenhagen and Aarhus, Denmark.PARTICIPANTS: Adults aged 50-64 years enrolled in the Danish Diet, Cancer, and Health cohort were followed up from baseline (1993-1997) in the National Patients Registry for first-time admissions for asthma and vital status. We defined incident asthma as at least one first-time hospital admission with asthma as the primary registered diagnosis between baseline and end of follow-up (2013) in participants without previously known asthma. Among the cohort comprising 57 053 individuals, we identified 785 adults (aged 50-64) with incident asthma, of whom 76 died during follow-up.PRIMARY AND SECONDARY OUTCOME MEASURES: Baseline reported socioeconomic and lifestyle traits, and comorbidities associated with all-cause mortality.RESULTS: Self-reported leisure-time physical activity was associated with a substantial reduction in risk with an HR of 0.53 (95% CI 0.33 to 0.85). Being male, single and having a diagnosis of hypertension or diabetes were associated with an increased risk of all-cause mortality with an HR of 1.83 (95% CI 1.14 to 2.38), 2.16 (95% CI 2.06 to 4.40), 2.47 (95% CI 1.54 to 3.95) and of 2.42 (95% CI 0.96 to 6.11), respectively.CONCLUSIONS: This long-term study of adults with hospital contacts for incident asthma revealed that self-reported leisure-time physical activity is associated with an approximately 50% reduction in all-cause mortality. In contrast, both hypertension and diabetes were associated with a higher risk of mortality.

AB - OBJECTIVE: We aimed to identify factors associated with all-cause mortality in adults with incident asthma.DESIGN AND SETTING: Cross-sectional cohort study, in the metropolitan areas of Copenhagen and Aarhus, Denmark.PARTICIPANTS: Adults aged 50-64 years enrolled in the Danish Diet, Cancer, and Health cohort were followed up from baseline (1993-1997) in the National Patients Registry for first-time admissions for asthma and vital status. We defined incident asthma as at least one first-time hospital admission with asthma as the primary registered diagnosis between baseline and end of follow-up (2013) in participants without previously known asthma. Among the cohort comprising 57 053 individuals, we identified 785 adults (aged 50-64) with incident asthma, of whom 76 died during follow-up.PRIMARY AND SECONDARY OUTCOME MEASURES: Baseline reported socioeconomic and lifestyle traits, and comorbidities associated with all-cause mortality.RESULTS: Self-reported leisure-time physical activity was associated with a substantial reduction in risk with an HR of 0.53 (95% CI 0.33 to 0.85). Being male, single and having a diagnosis of hypertension or diabetes were associated with an increased risk of all-cause mortality with an HR of 1.83 (95% CI 1.14 to 2.38), 2.16 (95% CI 2.06 to 4.40), 2.47 (95% CI 1.54 to 3.95) and of 2.42 (95% CI 0.96 to 6.11), respectively.CONCLUSIONS: This long-term study of adults with hospital contacts for incident asthma revealed that self-reported leisure-time physical activity is associated with an approximately 50% reduction in all-cause mortality. In contrast, both hypertension and diabetes were associated with a higher risk of mortality.

KW - adult thoracic medicine

KW - asthma

KW - epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85116866347&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2021-049243

DO - 10.1136/bmjopen-2021-049243

M3 - Journal article

C2 - 34607861

VL - 11

SP - 1

EP - 7

JO - BMJ Paediatrics Open

JF - BMJ Paediatrics Open

SN - 2044-6055

IS - 10

M1 - e049243

ER -

ID: 68332565