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Hvidovre Hospital - a part of Copenhagen University Hospital
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Cytokines and the Risk of Preterm Delivery in Twin Pregnancies

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  • Line Rode
  • Katharina Klein
  • Helle Larsen
  • Anni Holmskov
  • Kirsten Riis Andreasen
  • Niels Uldbjerg
  • Jan Ramb
  • Birgit Bødker
  • Lillian Skibsted
  • Lene Sperling
  • Stefan Hinterberger
  • Lone Krebs
  • Helle Zingenberg
  • Eva-Christine Weiss
  • Isolde Strobl
  • Lone Laursen
  • Jeanette Tranberg Christensen
  • Kristin Skogstrand
  • David Michael Hougaard
  • Elisabeth Krampl-Bettelheim
  • Susanne Rosthøj
  • Ida Vogel
  • Ann Tabor
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OBJECTIVE:: To estimate the association between cytokine levels in twin pregnancies and risk of spontaneous preterm delivery, including the effect of progesterone treatment. METHODS:: This secondary analysis of a randomized placebo-controlled trial investigating the effect of progesterone treatment on preterm delivery in twin pregnancies included 523 women with available dried blood spot samples collected before treatment with progesterone (n=258) or placebo (n=265) and after 4-8 weeks of treatment. Samples were analyzed for cytokines using a sandwich immunoassay. Cytokine levels in spontaneous preterm delivery at 34-37 weeks of gestation and spontaneous preterm delivery before 34 weeks of gestation were compared with delivery at 37 weeks of gestation or more for placebo-treated women. The association between interleukin (IL)-8 and risk of spontaneous preterm delivery before 34 weeks of gestation was estimated further, including comparison according to treatment. Statistical analyses included Kruskal-Wallis test, Mann-Whitney U test, linear regression, and Cox regression analysis. RESULTS:: We found a statistically significant association between IL-8 and spontaneous preterm delivery. At 23-33 weeks of gestation, the median IL-8 level was 52 pg/mL (interquartile range 39-71, range 19-1,061) for term deliveries compared with 65 pg/mL (interquartile range 43-88, range 14-584) for spontaneous preterm delivery at 34-37 weeks of gestation and 75 pg/mL (interquartile range 57-102, range 22-1,715) for spontaneous preterm delivery before 34 weeks of gestation (P
Original languageEnglish
JournalObstetrics and Gynecology
Volume120
Issue number1
Pages (from-to)60-68
Number of pages9
ISSN0029-7844
DOIs
Publication statusPublished - 2012

ID: 36287689