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Hvidovre Hospital - a part of Copenhagen University Hospital

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

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Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.
Original languageEnglish
Title of host publicationProceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages1
PublisherThe International Society for Magnetic Resonance in Medicine
Publication date2020
Article number1853
Publication statusPublished - 2020

ID: 62050590