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Hvidovre Hospital - a part of Copenhagen University Hospital
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Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study

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  • Maria Buhl Borgstrøm
  • Marie Louise Grøndahl
  • Tobias Wirenfeldt Klausen
  • Anne Kjærgaard Danielsen
  • Thordis Thomsen
  • Anette Gabrielsen
  • Anne Zedeler
  • Betina Boel Povlsen
  • Christina Hnida
  • Gitte Juul Almind
  • Jens Fedder
  • John Kirk
  • Johnny Hindkjær
  • Josephine G Lemmen
  • Karsten Petersen
  • Katrine Haahr
  • Morten Rønn Petersen
  • Steen Laursen
  • Thomas Høst Hansen
  • Ulla Breth Knudsen
  • Ursula Bentin-Ley
  • Thomas Larsen
  • Ulrik Schiøler Kesmodel
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OBJECTIVE: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.

DESIGN: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.

SETTING: Sixteen private and university-based facilities.

PATIENT(S): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): The competent blastocyst development stage (1-6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value.

RESULT(S): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18-24 years and 25-29 years in both COS and FET showed significantly lower levels in the youngest women.

CONCLUSION(S): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age.

Original languageEnglish
JournalFertility and Sterility
Volume115
Issue number3
Pages (from-to)646-654
Number of pages9
ISSN0015-0282
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • competent blastocyst, implantation, morphology, Women's age

ID: 61405922