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Hvidovre Hospital - en del af Københavns Universitetshospital
Udgivet

Using electronic patient records to discover disease correlations and stratify patient cohorts

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  • Francisco S. Roque
  • Peter B Jensen
  • Henriette Schmock
  • Marlene Dalgaard
  • Massimo Andreatta
  • Thomas Hansen
  • Karen Søeby
  • Søren Bredkjær
  • Anders Juul
  • Thomas Werge
  • Lars J Jensen
  • Søren Brunak
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Electronic patient records remain a rather unexplored, but potentially rich data source for discovering correlations between diseases. We describe a general approach for gathering phenotypic descriptions of patients from medical records in a systematic and non-cohort dependent manner. By extracting phenotype information from the free-text in such records we demonstrate that we can extend the information contained in the structured record data, and use it for producing fine-grained patient stratification and disease co-occurrence statistics. The approach uses a dictionary based on the International Classification of Disease ontology and is therefore in principle language independent. As a use case we show how records from a Danish psychiatric hospital lead to the identification of disease correlations, which subsequently can be mapped to systems biology frameworks.
OriginalsprogEngelsk
TidsskriftP L o S Computational Biology
Vol/bind7
Udgave nummer8
Sider (fra-til)e1002141
Antal sider10
ISSN1553-734X
DOI
StatusUdgivet - 1 aug. 2011

ID: 32767485